Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | AHR | P35869 | 1/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.45 |
| ▸ | KCNK3 | O14649 | 3/20 | 0.45 |
| ▸ | KCNK9 | Q9NPC2 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 4/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6618633 | 0.85 | HSD11B1 (0.42) | CASP3MAPTRAB9ASMN1; SMN2MAPK1 | |
| SCHEMBL6619441 | 0.82 | MAPT (0.48) | MAPTKMT2ARAB9ASMN1; SMN2MEN1 | |
| SCHEMBL6615384 | 0.81 | TP53 (0.45) | CASP3MAPTKMT2ANPC1RAB9A | |
| SCHEMBL6619084 | 0.81 | RAB9A (0.45) | MAPTKMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6615512 | 0.80 | ALDH1A1 (0.43) | CASP3MAPTKMT2ANPC1RAB9A | |
| SCHEMBL6615822 | 0.80 | KCNMA1 (0.41) | CASP3MAPTKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL6616043 | 0.80 | MAPT (0.43) | CASP3MAPTKMT2ANPC1RAB9A | |
| SCHEMBL6618884 | 0.79 | POLB (0.42) | CASP3MAPTKMT2ANPC1RAB9A | |
| SCHEMBL6604618 | 0.79 | RAB9A (0.40) | MAPTKMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6617028 | 0.79 | KDM4C (0.42) | KMT2AMEN1MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |