Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 5/20 | 0.51 |
| ▸ | DRD3 | P35462 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.43 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ADRB1 | P08588 | 6/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HTR3E | A5X5Y0 | 3/20 | 0.40 |
| ▸ | HTR3B | O95264 | 3/20 | 0.40 |
| ▸ | HTR3A | P46098 | 3/20 | 0.40 |
| ▸ | HTR3D | Q70Z44 | 3/20 | 0.40 |
| ▸ | HTR3C | Q8WXA8 | 3/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5349708 | 0.82 | HTR6 (0.51) | HTR6DRD3MAPTALDH1A1ITGB3 | |
| SCHEMBL15638490 | 0.74 | HTR2A (0.56) | ALDH1A1CYP1A2CYP3A4CYP2D6HTR2A | |
| SCHEMBL21635505 | 0.74 | CHRM2 (0.49) | DRD3MAPTALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL12813197 | 0.74 | ATAD2 (0.40) | MAPTALDH1A1MAPK1POLBCYP1A2 | |
| SCHEMBL4985572 | 0.71 | NOTUM (0.57) | HTR6DRD3MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL7202158 | 0.70 | HTR6 (0.61) | HTR6DRD3ADRB1HTR3EHTR3B | |
| SCHEMBL21635497 | 0.70 | HDAC1 (0.46) | DRD3SMN1; SMN2HTR2CHTR2B | |
| SCHEMBL466270 | 0.70 | ALDH1A1 (0.63) | MAPTALDH1A1POLBCHRM2CHRM4 | |
| SCHEMBL931075 | 0.69 | SIGMAR1 (0.48) | SIGMAR1CYP1A2HTR1ACYP2D6HTR2A | |
| SCHEMBL1758061 | 0.68 | ADRB1 (0.55) | HTR6ALDH1A1ADRB1HTR3EHTR3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451158-A1 | THERAPEUTIC QUINOLINE COMPOUNDS WITH 5-HT-ANTAGONISTIC PROPERTIES | AstraZeneca AB (SE) | 2004-09-01 | — | — | EP | disclosed |
| WO-2003037872-A1 | THERAPEUTIC QUINOLINE COMPOUNDS WITH 5-HT-ANTAGONISTIC PROPERTIES | ASTRAZENECA AB (SE) | 2003-05-08 | — | — | WO | disclosed |