Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.39 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | SMO | Q99835 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SLC13A5 | Q86YT5 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6618519 | 0.91 | ALDH1A1 (0.42) | MEN1KMT2AALDH1A1POLBCYP3A4 | |
| SCHEMBL6618768 | 0.91 | MEN1 (0.46) | MEN1KMT2AALDH1A1POLBMAPT | |
| SCHEMBL6621361 | 0.91 | JAK2 (0.43) | MEN1KMT2APOLBSMN1; SMN2 | |
| SCHEMBL6614362 | 0.88 | HRH3 (0.43) | MEN1KMT2AALDH1A1TSHRPOLB | |
| SCHEMBL6618467 | 0.87 | RAB9A (0.39) | MEN1KMT2AALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL6675449 | 0.86 | HPGD (0.43) | MEN1KMT2AALDH1A1TSHRPOLB | |
| SCHEMBL6616066 | 0.86 | KMT2A (0.39) | MEN1KMT2AALDH1A1POLBCYP3A4 | |
| SCHEMBL6622866 | 0.86 | KDM4E (0.40) | MEN1KMT2AALDH1A1POLBMAPT | |
| SCHEMBL6614450 | 0.86 | ALDH1A1 (0.41) | MEN1KMT2AALDH1A1POLBERCC1 | |
| SCHEMBL6617100 | 0.86 | NPC1 (0.40) | MEN1KMT2AALDH1A1POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |