Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | NOS3 | P29474 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
| ▸ | NOS2 | P35228 | 1/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | TYMS | P04818 | 2/20 | 0.32 |
| ▸ | NQO2 | P16083 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4464552 | 0.72 | MAPT (0.50) | KMT2AMEN1KDM4ECYP3A4LMNA | |
| SCHEMBL9983598 | 0.71 | PKM (0.33) | — | |
| SCHEMBL6998636 | 0.71 | TYMS (0.35) | KMT2AMEN1TYMSLMNA | |
| SCHEMBL29694275 | 0.69 | ALDH1A1 (0.45) | ALDH1A1KMT2AMEN1USP2HPGD | |
| SCHEMBL2811653 | 0.69 | PKM (0.31) | — | |
| SCHEMBL496870 | 0.68 | MAPKAPK2 (0.36) | ALDH1A1KMT2AMEN1HPGDHSD17B10 | |
| SCHEMBL30538321 | 0.67 | MAPT (0.52) | ALDH1A1KMT2AMEN1HSD17B10KDM4E | |
| SCHEMBL18839387 | 0.67 | PDE3B (0.34) | KMT2AMEN1 | |
| SCHEMBL7368978 | 0.65 | LMNA (0.61) | ALDH1A1KMT2AMEN1USP2NOS3 | |
| SCHEMBL7364735 | 0.65 | LMNA (0.40) | ALDH1A1KMT2AMEN1HSD17B10DHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1196418-B1 | METHOD FOR PREPARING SUBSTITUTED 1,4]DIAZEPINO 6,7,1- i hi /i ]INDOL-4-ONES | WARNER LAMBERT CO (US) | 2004-06-16 | — | — | EP | claimed |
| EP-1196418-A1 | METHOD FOR PREPARING SUBSTITUTED 1,4]DIAZEPINO 6,7,1- i hi /i ]INDOL-4-ONES | WARNER-LAMBERT COMPANY (US) | 2002-04-17 | — | — | EP | claimed |
| WO-2001002403-A1 | METHOD FOR PREPARING SUBSTITUTED [1,4]DIAZEPINO[6,7,1-hi]INDOL-4-ONES | WARNER-LAMBERT COMPANY (US) | 2001-01-11 | — | — | WO | claimed |
| CN-1166668-C | Method for preparing substituted [1,4] diazepino (6,7,1-hi) indol-4-ones | ��ʲ | 2004-09-15 | — | — | CN | disclosed |
| EP-1196418-B1 | METHOD FOR PREPARING SUBSTITUTED 1,4]DIAZEPINO 6,7,1- i hi /i ]INDOL-4-ONES | WARNER LAMBERT CO (US) | 2004-06-16 | — | — | EP | disclosed |
| EP-1196418-B1 | METHOD FOR PREPARING SUBSTITUTED 1,4]DIAZEPINO 6,7,1- i hi /i ]INDOL-4-ONES | WARNER LAMBERT CO (US) | 2004-06-16 | — | — | EP | disclosed |
| US-6689881-B1 | Method for preparing substituted [1,4]diazepino[6,7,1-hi]indol-4-ones | WARNER-LAMBERT LLC | 2004-02-10 | — | — | US | disclosed |
| US-6689881-B1 | Method for preparing substituted [1,4]diazepino[6,7,1-hi]indol-4-ones | WARNER-LAMBERT LLC | 2004-02-10 | — | — | US | disclosed |
| US-20020119967-A1 | Pharmaceutical composition for preventing or treating a disease associated with an excess of IL-12-production | WARNER-LAMBERT COMPANY | 2002-08-29 | — | — | US | disclosed |
| CN-1362960-A | Process for the preparation of substituted [1,4] -diaza * o [6,7, 1-hi ] -indol-4-ones | WARNER LAMBERT CO (US) | 2002-08-07 | — | — | CN | disclosed |
| WO-2002022112-A9 | PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING A DISEASE ASSOCIATED WITH AN EXCESS OF IL-12 PRODUCTION | WARNER LAMBERT CO (US) | 2002-06-06 | — | — | WO | disclosed |
| EP-1199074-A1 | Pharmaceutical composition for preventing or treating a disease associated with an excess of il-12 production | WARNER-LAMBERT COMPANY (US) | 2002-04-24 | — | — | EP | disclosed |
| EP-1196418-A1 | METHOD FOR PREPARING SUBSTITUTED 1,4]DIAZEPINO 6,7,1- i hi /i ]INDOL-4-ONES | WARNER-LAMBERT COMPANY (US) | 2002-04-17 | — | — | EP | disclosed |
| EP-1196418-A1 | METHOD FOR PREPARING SUBSTITUTED 1,4]DIAZEPINO 6,7,1- i hi /i ]INDOL-4-ONES | WARNER-LAMBERT COMPANY (US) | 2002-04-17 | — | — | EP | disclosed |
| EP-1188438-A1 | Pharmaceutical composition for preventing or treating a disease associated with an excess of Il-12 production | WARNER-LAMBERT COMPANY (US) | 2002-03-20 | — | — | EP | disclosed |
| WO-2001002403-A1 | METHOD FOR PREPARING SUBSTITUTED [1,4]DIAZEPINO[6,7,1-hi]INDOL-4-ONES | WARNER-LAMBERT COMPANY (US) | 2001-01-11 | — | — | WO | disclosed |
| WO-2001002403-A1 | METHOD FOR PREPARING SUBSTITUTED [1,4]DIAZEPINO[6,7,1-hi]INDOL-4-ONES | WARNER-LAMBERT COMPANY (US) | 2001-01-11 | — | — | WO | disclosed |