Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMS | P04818 | 8/20 | 0.35 |
| ▸ | PARP1 | P09874 | 2/20 | 0.35 |
| ▸ | QTRT1 | Q9BXR0 | 1/20 | 0.35 |
| ▸ | CASP6 | P55212 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.33 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.33 |
| ▸ | S100A4 | P26447 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 2/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.32 |
| ▸ | FLT1 | P17948 | 2/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6623124 | 0.71 | ALDH1A1 (0.37) | TYMSMEN1LMNAKMT2A | |
| SCHEMBL31179118 | 0.66 | MAP4K4 (0.41) | MEN1LMNAHSP90AA1HSP90AB1MAPT | |
| SCHEMBL6784749 | 0.61 | PARP1 (0.51) | PARP1MEN1LMNAHSP90AA1HSP90AB1 | |
| SCHEMBL496870 | 0.60 | MAPKAPK2 (0.36) | MEN1MAPTKMT2A | |
| SCHEMBL7364735 | 0.60 | LMNA (0.40) | MEN1LMNAHSP90AA1HSP90AB1MAPT | |
| SCHEMBL13859950 | 0.60 | MAPT (0.54) | MEN1LMNAHSP90AA1HSP90AB1MAPT | |
| SCHEMBL7368978 | 0.60 | LMNA (0.61) | MEN1LMNAHSP90AA1MAPTHTT | |
| SCHEMBL3238859 | 0.59 | GPR3 (0.45) | LMNAMAPTHTTKMT2A | |
| SCHEMBL27165288 | 0.59 | GPR3 (0.45) | PARP1QTRT1MEN1LMNABLM | |
| SCHEMBL8673305 | 0.59 | LMNA (0.37) | LMNAMAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0980374-B1 | PHOSPHODIESTERASE 4-INHIBITING DIAZEPINOINDOLONES | PFIZER HOLDING FRANCE (FR) | 2003-02-12 | — | — | EP | claimed |