Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4F2 | P78329 | 5/20 | 0.47 |
| ▸ | CYP4A11 | Q02928 | 5/20 | 0.47 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.36 |
| ▸ | RXRA | P19793 | 1/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | STAT3 | P40763 | 1/20 | 0.36 |
| ▸ | RHEB | Q15382 | 1/20 | 0.35 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.35 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.35 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.35 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.35 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.35 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.35 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL663584 | 0.86 | CYP4F2 (0.45) | CYP4F2CYP4A11TRPV1RXRANR1H2 | |
| SCHEMBL22032139 | 0.80 | CYP4A11 (0.43) | CYP4F2CYP4A11PPARARXRANR1H2 | |
| SCHEMBL664561 | 0.80 | CYP4F2 (0.45) | CYP4F2CYP4A11PPARACA12CA1 | |
| SCHEMBL14969491 | 0.78 | CYP4F2 (0.43) | CYP4F2CYP4A11ALDH1A1KDM4EGAA | |
| SCHEMBL7858859 | 0.78 | ALDH1A1 (0.53) | ALDH1A1MAPT | |
| SCHEMBL22084670 | 0.77 | NPC1 (0.54) | CYP4F2CYP4A11ALDH1A1KDM4EGAA | |
| SCHEMBL664212 | 0.76 | ALDH1A1 (0.55) | MRGPRX4PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL1016954 | 0.76 | NPC1 (0.41) | CYP4F2CYP4A11PPARACA12CA1 | |
| SCHEMBL27688090 | 0.75 | NPC1 (0.41) | CYP4F2CYP4A11RXRANR1H2CA12 | |
| SCHEMBL24269548 | 0.75 | NR1H4 (0.43) | CYP4F2CYP4A11NR1H2CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120046293-A1 | RENIN INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2012-02-23 | — | — | US | disclosed |
| US-8063105-B2 | Renin inhibitors | MERCK CANADA INC. (CA) | 2011-11-22 | — | — | US | disclosed |
| US-20090281103-A1 | Renin Inhibitors | MERCK CANADA INC. (CA) | 2009-11-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120046293-A1 | RENIN INHIBITORS | REN, ACE, AGTR1 | CYP4F2 562/4885CYP4A11 231/4885PPARA 1405/4885 |
| US-20090281103-A1 | Renin Inhibitors | REN, ACE, AGT | CYP4F2 257/4885CYP4A11 53/4885PPARA 2696/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.