Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4F2 | P78329 | 1/20 | 0.45 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 2/20 | 0.39 |
| ▸ | PPARD | Q03181 | 2/20 | 0.39 |
| ▸ | XDH | P47989 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.37 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL662462 | 0.80 | CYP4F2 (0.47) | CYP4F2CYP4A11PPARAALDH1A1ALOX5 | |
| SCHEMBL663584 | 0.78 | CYP4F2 (0.45) | CYP4F2CYP4A11CYP3A4MEN1KMT2A | |
| SCHEMBL663578 | 0.77 | ALDH1A1 (0.52) | PTGS1CYP3A4MEN1KMT2ATDP1 | |
| SCHEMBL22032181 | 0.76 | MAPT (0.39) | CYP4F2CYP4A11ALDH1A1HPGDMAPT | |
| SCHEMBL7858859 | 0.76 | ALDH1A1 (0.53) | MEN1KMT2ATDP1L3MBTL1ALDH1A1 | |
| SCHEMBL14415228 | 0.75 | SLC7A5 (0.59) | CYP4F2CYP4A11PTGS1CYP3A4MEN1 | |
| SCHEMBL24269548 | 0.73 | NR1H4 (0.43) | CYP4F2CYP4A11CYP3A4MEN1KMT2A | |
| SCHEMBL29590117 | 0.73 | NR1H4 (0.43) | CYP4F2CYP4A11CYP3A4MEN1KMT2A | |
| SCHEMBL27684346 | 0.73 | GABRG2 (0.43) | CYP4F2CYP4A11MEN1KMT2AALDH1A1 | |
| SCHEMBL147388 | 0.73 | ALDH1A1 (0.54) | MEN1KMT2ATDP1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120046293-A1 | RENIN INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2012-02-23 | — | — | US | disclosed |
| US-8063105-B2 | Renin inhibitors | MERCK CANADA INC. (CA) | 2011-11-22 | — | — | US | disclosed |
| US-20090281103-A1 | Renin Inhibitors | MERCK CANADA INC. (CA) | 2009-11-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120046293-A1 | RENIN INHIBITORS | REN, ACE, AGTR1 | CYP4F2 562/4885CYP4A11 231/4885PTGS1 454/4885 |
| US-20090281103-A1 | Renin Inhibitors | REN, ACE, AGT | CYP4F2 257/4885CYP4A11 53/4885PTGS1 387/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.