Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4F2 | P78329 | 1/20 | 0.45 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | STAT3 | P40763 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | PTGES | O14684 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | RXRA | P19793 | 1/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL662462 | 0.86 | CYP4F2 (0.47) | CYP4F2CYP4A11TRPV1STAT3ALDH1A1 | |
| SCHEMBL664960 | 0.81 | MRGPRX4 (0.50) | CYP4F2CYP4A11HPGDLMNATSHR | |
| SCHEMBL14969491 | 0.78 | CYP4F2 (0.43) | CYP4F2CYP4A11HPGDLMNATSHR | |
| SCHEMBL664561 | 0.78 | CYP4F2 (0.45) | CYP4F2CYP4A11HPGDSTAT3ALDH1A1 | |
| SCHEMBL7858859 | 0.76 | ALDH1A1 (0.53) | HPGDLMNATSHRALDH1A1MAPT | |
| SCHEMBL30647595 | 0.75 | LMNA (0.42) | LMNATRPV1CYP1A2RXRANR1H2 | |
| SCHEMBL31510607 | 0.75 | LMNA (0.42) | LMNATRPV1CYP1A2RXRANR1H2 | |
| SCHEMBL22084670 | 0.74 | NPC1 (0.54) | CYP4F2CYP4A11ALDH1A1MAPTKMT2A | |
| SCHEMBL1930540 | 0.74 | ALDH1A1 (0.55) | HPGDLMNASTAT3TSHRALDH1A1 | |
| SCHEMBL15471912 | 0.73 | CYP4F2 (0.46) | CYP4F2CYP4A11HPGDLMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120046293-A1 | RENIN INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2012-02-23 | — | — | US | disclosed |
| US-8063105-B2 | Renin inhibitors | MERCK CANADA INC. (CA) | 2011-11-22 | — | — | US | disclosed |
| US-20090281103-A1 | Renin Inhibitors | MERCK CANADA INC. (CA) | 2009-11-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120046293-A1 | RENIN INHIBITORS | REN, ACE, AGTR1 | CYP4F2 562/4885CYP4A11 231/4885HPGD 559/4885 |
| US-20090281103-A1 | Renin Inhibitors | REN, ACE, AGT | CYP4F2 257/4885CYP4A11 53/4885HPGD 523/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.