Sugi Predict

Sugi Predict / Compounds / SCHEMBL6627375

SCHEMBL6627375

SCHEMBL6627375

O=[N+]([O-])c1cccc(C(=NO)C(F)(F)F)c1

nearest known ligand 0.56

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ CES2 O00748 1/20 0.56
▸ CES1 P23141 1/20 0.56
▸ TP53 P04637 1/20 0.54
▸ ALDH1A1 P00352 5/20 0.53
▸ TSHR P16473 4/20 0.53
▸ PRSS1 P07477 1/20 0.50
▸ PRSS2 P07478 1/20 0.50
▸ PRSS3 P35030 1/20 0.50
▸ LMNA P02545 1/20 0.48
▸ KMT2A Q03164 3/20 0.48
▸ MEN1 O00255 2/20 0.48
▸ POLB P06746 3/20 0.47
▸ MAPT P10636 2/20 0.47
▸ CTDSP1 Q9GZU7 1/20 0.47
▸ ALOX15 P16050 1/20 0.46
▸ RXFP1 Q9HBX9 1/20 0.44
▸ RAB9A P51151 2/20 0.44
▸ NPC1 O15118 1/20 0.44
▸ HTT P42858 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6851521 1.00 CES2 (0.56) CES2CES1TP53ALDH1A1TSHR
SCHEMBL9799783 0.88 CES2 (0.53) CES2CES1TP53ALDH1A1TSHR
SCHEMBL9799580 0.88 ALDH1A1 (0.54) CES2CES1TP53ALDH1A1TSHR
SCHEMBL9799777 0.88 CES2 (0.53) CES2CES1TP53ALDH1A1TSHR
SCHEMBL24683843 0.79 GAA (0.50) CES2CES1ALDH1A1TSHRKMT2A
SCHEMBL923488 0.79 CES2 (0.66) CES2CES1TP53ALDH1A1TSHR
SCHEMBL27963505 0.79 CES2 (0.61) CES2CES1TP53ALDH1A1TSHR
SCHEMBL18029679 0.78 PRSS1 (0.61) CES2CES1TP53ALDH1A1TSHR
SCHEMBL540105 0.78 CES2 (0.59) CES2CES1TP53ALDH1A1TSHR
SCHEMBL30755343 0.78 CES2 (0.59) CES2CES1TP53ALDH1A1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240400502-A1 SULFONYLUREAS AND RELATED COMPOUNDS AND USE OF SAME UNIV QUEENSLAND (AU) 2024-12-05 — — US disclosed
US-11845715-B2 — — 2023-12-19 — — US disclosed
US-11845715-B2 — — 2023-12-19 — — US disclosed
US-20220112159-A1 SULFONYLUREAS AND RELATED COMPOUNDS AND USE OF SAME UNIV QUEENSLAND (AU) 2022-04-14 — — US disclosed
CN-113582889-A Sulfonylureas and related compounds and uses thereof 昆士兰大学 2021-11-02 — — CN disclosed
CN-113563264-A Sulfonylureas and related compounds and uses thereof 昆士兰大学 2021-10-29 — — CN disclosed
EP-3888749-A1 SULFONYLUREAS AND RELATED COMPOUNDS AND USE OF SAME The University of Queensland (AU) 2021-10-06 — — EP disclosed
US-11130731-B2 Sulfonylureas and related compounds and use of same THE PROVOST, FELLOWS, FOUNDATION SCHOLARS, AND THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN (IE) 2021-09-28 — — US disclosed
CN-107428696-B Sulfonylureas and related compounds and uses thereof 昆士兰大学 2021-08-20 — — CN disclosed
EP-3578547-A1 SULFONYLUREAS AND RELATED COMPOUNDS AND USE OF SAME The University of Queensland (AU) 2019-12-11 — — EP disclosed
US-20030166650-A1 Cinnamide derivatives as KCNQ potassium channel modulators BRISTOL-MYERS SQUIBB COMPANY 2003-09-04 — — US disclosed
WO-2002096858-A1 CINNAMIDE DERIVATIVES AS KCNQ POTASSIUM CHANNEL MODULATORS BRISTOL-MYERS SQUIBB COMPANY (US) 2002-12-05 — — WO disclosed
US-5041663-A Plant safening agents CIBA-GEIGY CORPORATION (US) 1991-08-20 — — US disclosed
US-5032169-A Antidotes for herbicides CIBA-GEIGY CORPORATION (US) 1991-07-16 — — US disclosed
US-4759789-A Treating locus of plant before or during application of herbicide with oxime ether compound CIBA-GEIGY CORPORATION (US) 1988-07-26 — — US disclosed
US-4707182-A Phenoxine-ketal ethers, compositions containing them and the use thereof CIBA-GEIGY CORPORATION (US) 1987-11-17 — — US disclosed
US-4648895-A ANTIDOTES CIBA-GEIGY CORPORATION (US) 1987-03-10 — — US disclosed
US-4576628-A PLANT SAFENING AGENTS CIBA-GEIGY CORPORATION (US) 1986-03-18 — — US disclosed
US-4566901-A PLANT SAFENING AGENTS CIBA-GEIGY CORPORATION (US) 1986-01-28 — — US disclosed
US-4530716-A Plant safening agent CIBA-GEIGY CORPORATION (US) 1985-07-23 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220112159-A1 SULFONYLUREAS AND RELATED COMPOUNDS AND USE OF SAME NLRP3, PYCARD, IAPP CES2 2826/4885CES1 1159/4885TP53 2564/4885
US-11845715-B2 — NLRP3, PYCARD, NOD1 CES2 2956/4885CES1 1068/4885TP53 1086/4885
US-11130731-B2 Sulfonylureas and related compounds and use of same NLRP3, PYCARD, IAPP CES2 2826/4885CES1 1159/4885TP53 2564/4885
US-20030166650-A1 Cinnamide derivatives as KCNQ potassium channel modulators KCNH2, KCNH3, KCNQ1 CES2 665/4885CES1 438/4885TP53 4853/4885
US-20240400502-A1 SULFONYLUREAS AND RELATED COMPOUNDS AND USE OF SAME NLRP3, PYCARD, IAPP CES2 2826/4885CES1 1159/4885TP53 2564/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.