Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.34 |
| ▸ | AGXT | P21549 | 1/20 | 0.34 |
| ▸ | MRGPRX4 | Q96LA9 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.33 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | RXRA | P19793 | 1/20 | 0.33 |
| ▸ | RXRB | P28702 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6602304 | 0.83 | CASP1 (0.39) | CASP1AGXTMRGPRX4 | |
| SCHEMBL6947156 | 0.83 | CASP1 (0.53) | CASP1L3MBTL1 | |
| SCHEMBL9506098 | 0.78 | L3MBTL1 (0.53) | CASP1L3MBTL1 | |
| SCHEMBL28516086 | 0.77 | L3MBTL1 (0.55) | CASP1L3MBTL1 | |
| Trifluoroacetic Acid SCHEMBL6601200 | 0.74 | CASP1 (0.57) | CASP1L3MBTL1 | |
| SCHEMBL10585304 | 0.73 | NPY1R (0.45) | CASP1 | |
| SCHEMBL1934716 | 0.73 | ALDH1A1 (0.50) | CASP1L3MBTL1 | |
| SCHEMBL10584104 | 0.70 | RAB9A (0.52) | CASP1L3MBTL1NPC1RAB9APOLB | |
| SCHEMBL1027741 | 0.64 | — | — | |
| SCHEMBL21281736 | 0.64 | CASP1 (0.53) | CASP1L3MBTL1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1444202-A1 | NOVEL METALLOPROTEINASE INHIBITORS | AstraZeneca AB (SE) | 2004-08-11 | — | — | EP | disclosed |
| WO-2003040098-A1 | NOVEL METALLOPROTEINASE INHIBITORS | ASTRAZENECA AB (SE) | 2003-05-15 | — | — | WO | disclosed |