Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.55 |
| ▸ | LMNA | P02545 | 4/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | HTR7 | P34969 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5646848 | 0.83 | ALDH1A1 (0.49) | ALDH1A1SMN1; SMN2LMNAMAPTPOLB | |
| SCHEMBL28106920 | 0.79 | GAA (0.56) | ALDH1A1SMN1; SMN2LMNAMAPTPOLB | |
| SCHEMBL23648904 | 0.72 | L3MBTL1 (0.54) | ALDH1A1SMN1; SMN2LMNAMAPTPOLB | |
| SCHEMBL28571133 | 0.70 | HRH3 (0.43) | ALDH1A1TP53 | |
| SCHEMBL9128289 | 0.69 | LSS (0.55) | ALDH1A1SMN1; SMN2LMNAMAPTPOLB | |
| SCHEMBL8840166 | 0.69 | TBXA2R (0.64) | ALDH1A1SMN1; SMN2POLB | |
| SCHEMBL23928222 | 0.69 | KMT2A (0.53) | ALDH1A1HTR2AHTR2C | |
| SCHEMBL9127531 | 0.69 | LTA4H (0.59) | ALDH1A1SMN1; SMN2POLBHTTHTR7 | |
| SCHEMBL8971065 | 0.69 | TBXA2R (0.68) | ALDH1A1SMN1; SMN2LMNAMAPTPOLB | |
| SCHEMBL6629549 | 0.69 | ADAMTS4 (0.57) | ALDH1A1MAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458374-A2 | COMPOUNDS AND USES THEREOF FOR DECREASING ACTIVITY OF HORMONE-SENSITIVE LIPASE | NOVO NORDISK A/S (DK) | 2004-09-22 | — | — | EP | disclosed |
| WO-2003051841-A2 | COMPOUNDS AND USES THEREOF FOR DECREASING ACTIVITY OF HORMONE-SENSITIVE LIPASE | NOVO NORDISK A/S (DK) | 2003-06-26 | — | — | WO | disclosed |