Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIN1 | Q13526 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | APEX1 | P27695 | 1/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.38 |
| ▸ | LTA4H | P09960 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CRHBP | P24387 | 1/20 | 0.35 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2897638 | 0.86 | CYP2C9 (0.49) | TSHRCYP2C9SMN1; SMN2LMNAAPEX1 | |
| SCHEMBL2902878 | 0.80 | LMNA (0.40) | PIN1TSHRCYP2C9SMN1; SMN2LMNA | |
| SCHEMBL2897637 | 0.79 | LMNA (0.39) | TSHRCYP2C9SMN1; SMN2LMNAAPEX1 | |
| SCHEMBL2903002 | 0.79 | SMN1; SMN2 (0.42) | TSHRCYP2C9SMN1; SMN2LMNAAPEX1 | |
| SCHEMBL2901895 | 0.77 | HSPB1 (0.44) | PIN1SMN1; SMN2LMNAMEN1KMT2A | |
| SCHEMBL15924716 | 0.72 | MAPK8 (0.52) | PIN1TSHRCYP2C9SMN1; SMN2LMNA | |
| SCHEMBL27471024 | 0.71 | LTA4H (0.46) | PIN1TSHRCYP2C9SMN1; SMN2LTA4H | |
| SCHEMBL20243481 | 0.69 | LTA4H (0.48) | TSHRCYP2C9SMN1; SMN2LMNALTA4H | |
| SCHEMBL3060000 | 0.68 | KDM4E (0.39) | CYP2C9SMN1; SMN2LMNAMEN1KMT2A | |
| SCHEMBL4475588 | 0.68 | L3MBTL1 (0.35) | SMN1; SMN2L3MBTL1GAAHPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1444228-A2 | SUBSTITUTED HETEROARYLALKANOIC ACIDS AND THEIR USE AS ALDOSE REDUCTASE INHIBITORS | The Institutes for Pharmaceutical Discovery, LLC (US) | 2004-08-11 | — | — | EP | disclosed |
| WO-2003044015-A2 | SUBSTITUTED HETEROARYLALKANOIC ACIDS AND THEIR USE AS ALDOSE REDUCTASE INHIBITORS | THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY, LLC (US) | 2003-05-30 | — | — | WO | disclosed |