Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCAM1 | P19320 | 1/20 | 0.44 |
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.43 |
| ▸ | NOS3 | P29474 | 1/20 | 0.42 |
| ▸ | NOS1 | P29475 | 1/20 | 0.42 |
| ▸ | NOS2 | P35228 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | HTR1D | P28221 | 1/20 | 0.39 |
| ▸ | HTR1F | P30939 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22634604 | 0.74 | SIRT6 (0.64) | SIRT6ALDH1A1MAPTMAPK1HTR6 | |
| SCHEMBL11245061 | 0.72 | HTR6 (0.43) | CYP2D6HTR6 | |
| SCHEMBL824173 | 0.72 | GPR35 (0.50) | SIRT6TDP1ALDH1A1MAPTMAPK1 | |
| SCHEMBL14983036 | 0.71 | MAPT (0.44) | SIRT6NOS3NOS1NOS2TDP1 | |
| SCHEMBL1967596 | 0.70 | HSP90AA1 (0.58) | SIRT6ALDH1A1HPGDMAPK1SLC18A3 | |
| SCHEMBL392626 | 0.70 | HPGD (0.62) | VCAM1TDP1ALDH1A1HPGDMAPK1 | |
| SCHEMBL27229128 | 0.70 | LMNA (0.47) | VCAM1SIRT6NOS3NOS1NOS2 | |
| SCHEMBL22652203 | 0.70 | ALDH1A1 (0.62) | SIRT6ALDH1A1HPGDMAPTMAPK1 | |
| SCHEMBL11745901 | 0.70 | TSHR (0.54) | TDP1ALDH1A1HPGDMAPTMCOLN3 | |
| SCHEMBL11745892 | 0.70 | TSHR (0.54) | TDP1ALDH1A1HPGDMAPTMCOLN3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1377580-A2 | BENZENESULFONIC ACID INDOL-5-YL ESTERS AS ANTAGONISTS OF THE 5-HT6 RECEPTOR | ELI LILLY AND COMPANY (US) | 2004-01-07 | — | — | EP | claimed |
| WO-2002060871-A2 | BENZENESULFONIC ACID INDOL-5-YL ESTERS AS ANTAGONISTS OF THE 5-HT6 RECEPTOR | ELI LILLY AND COMPANY (US) | 2002-08-08 | — | — | WO | claimed |