Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TACR1 | P25103 | 2/20 | 0.37 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.37 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | FABP4 | P15090 | 1/20 | 0.36 |
| ▸ | PLK1 | P53350 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6637890 | 0.87 | FOLH1 (0.43) | BACE1FOLH1GABRA5TACR1FABP4 | |
| SCHEMBL6637281 | 0.83 | HSP90AA1 (0.49) | FOLH1TACR1AKR1C3AKR1C2FABP4 | |
| SCHEMBL6637411 | 0.78 | LTB4R (0.43) | ALDH1A1FOLH1GABRA5TACR1KDM4E | |
| SCHEMBL6682318 | 0.76 | TAS2R14 (0.50) | FOLH1GABRA5NOTUMTACR1FABP4 | |
| SCHEMBL27821178 | 0.74 | ALDH1A1 (0.45) | BACE1ALDH1A1FOLH1CYP2C19MEN1 | |
| SCHEMBL14446886 | 0.73 | MAOB (0.60) | ALDH1A1TACR1KDM4EMAOAMAOB | |
| SCHEMBL6639868 | 0.73 | PRKAB2 (0.44) | ALDH1A1FOLH1NOTUMAKR1C2FABP4 | |
| SCHEMBL6639317 | 0.72 | CFTR (0.44) | ALDH1A1NOTUMCYP2C19MEN1CYP1A2 | |
| SCHEMBL5067098 | 0.72 | ALDH1A1 (0.56) | BACE1ALDH1A1FOLH1KMT2A | |
| SCHEMBL6638442 | 0.72 | CYP3A4 (0.44) | ALDH1A1NOTUMMEN1KMT2ATACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1383760-A1 | BIARYLCARBOXAMIDE COMPOUNDS AS APOLIPOPROTEIN B INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2004-01-28 | — | — | EP | disclosed |
| WO-2002090347-A1 | AMIDE COMPOUNDS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-11-14 | — | — | WO | disclosed |