Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.65 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.65 |
| ▸ | RECQL | P46063 | 1/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.59 |
| ▸ | HRH1 | P35367 | 1/20 | 0.59 |
| ▸ | SLC25A20 | O43772 | 3/20 | 0.56 |
| ▸ | TP53 | P04637 | 3/20 | 0.56 |
| ▸ | TSHR | P16473 | 3/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.56 |
| ▸ | SLC6A5 | Q9Y345 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.56 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.56 |
| ▸ | THPO | P40225 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | CPT2 | P23786 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5085300 | 0.88 | LMNA (0.55) | MEN1KMT2ACYP2C19RECQLCYP1A2 | |
| SCHEMBL232682 | 0.81 | MEN1 (0.73) | MEN1KMT2ACYP2C19RECQLCYP1A2 | |
| SCHEMBL464880 | 0.81 | MEN1 (0.73) | MEN1KMT2ACYP2C19RECQLCYP1A2 | |
| SCHEMBL28508907 | 0.81 | MEN1 (0.73) | MEN1KMT2ACYP2C19RECQLCYP1A2 | |
| SCHEMBL16238330 | 0.81 | MEN1 (0.73) | MEN1KMT2ACYP2C19RECQLCYP1A2 | |
| SCHEMBL7048157 | 0.80 | MEN1 (0.77) | MEN1KMT2ACYP2C19RECQLCYP1A2 | |
| SCHEMBL3006635 | 0.80 | MEN1 (0.77) | MEN1KMT2ACYP2C19RECQLCYP1A2 | |
| Hydrochloric Acid SCHEMBL9465317 | 0.80 | MEN1 (0.71) | MEN1KMT2ACYP2C19RECQLCYP1A2 | |
| Potassium Ion SCHEMBL10496225 | 0.80 | MEN1 (0.71) | MEN1KMT2ACYP2C19RECQLCYP1A2 | |
| Hydrochloric Acid SCHEMBL17004055 | 0.80 | MEN1 (0.71) | MEN1KMT2ACYP2C19RECQLCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1162397-C | Therapeutically and/or nutritionaly enhanced derivatives of active ingredients and orally administrable compsns. contg. same | �����ι�˾ | 2004-08-18 | — | — | CN | disclosed |
| EP-1202956-B1 | THERAPEUTICALLY AND/OR NUTRITIONALLY ENHANCED DERIVATIVES OF ACTIVE INGREDIENTS AND ORALLY ADMINISTRABLE COMPOSITIONS CONTAINING SAME | SIGMA TAU IND FARMACEUTI (IT) | 2004-05-19 | — | — | EP | disclosed |
| US-6703042-B1 | STABLE, NON-HYGROSCOPIC; NUTRITIONAL SUPPLEMENTS | SIGMA-TAU INDUSTRIES FARMACEUTICHE RIUNITE S.P.A. (IT) | 2004-03-09 | — | — | US | disclosed |
| US-4883786-A | CARDIOTROPIC AGENTS | MAGIS FARMACEUTICI SRL (IT) | 1989-11-28 | — | — | US | disclosed |
| EP-0167115-B1 | NEW DERIVATIVES OF L-CARNITINE | MAGIS FARMACEUTICI S.P.A. (IT) | 1988-04-20 | — | — | EP | disclosed |
| EP-0167115-A2 | New derivatives of L-carnitine | MAGIS FARMACEUTICI S.P.A. (IT) | 1986-01-08 | — | — | EP | disclosed |