Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.64 |
| ▸ | CYP11B2 | P19099 | 7/20 | 0.57 |
| ▸ | CYP11B1 | P15538 | 6/20 | 0.57 |
| ▸ | CYP17A1 | P05093 | 5/20 | 0.57 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.57 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.54 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.54 |
| ▸ | QPCT | Q16769 | 1/20 | 0.53 |
| ▸ | QPCTL | Q9NXS2 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.50 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.49 |
| ▸ | PIP4K2B | P78356 | 1/20 | 0.49 |
| ▸ | FYN | P06241 | 1/20 | 0.49 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.49 |
| ▸ | ATR | Q13535 | 1/20 | 0.48 |
| ▸ | CCNC | P24863 | 1/20 | 0.47 |
| ▸ | CDK8 | P49336 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7497614 | 0.87 | FGFR1 (0.62) | CYP11B2CYP11B1CYP17A1CYP19A1FGFR1 | |
| Ethoxycarbonyl Group SCHEMBL28015039 | 0.83 | MMP2 (0.51) | NPC1CYP11B2CYP11B1CYP17A1CYP19A1 | |
| SCHEMBL1422788 | 0.82 | NPC1 (0.66) | NPC1ALDH1A1 | |
| SCHEMBL6655349 | 0.81 | NPC1 (0.59) | NPC1CYP11B2CYP11B1CYP17A1CYP3A4 | |
| SCHEMBL24222501 | 0.80 | PIK3CD (0.61) | NPC1CYP11B2CYP11B1CYP17A1GRM1 | |
| SCHEMBL5850255 | 0.80 | NPC1 (0.79) | NPC1CYP11B2CYP11B1CYP17A1CYP2A6 | |
| SCHEMBL3956542 | 0.79 | CYP17A1 (0.76) | NPC1CYP11B2CYP11B1CYP17A1CYP2A6 | |
| SCHEMBL446619 | 0.78 | NPC1 (1.00) | NPC1CYP11B2CYP11B1CYP17A1CYP2A6 | |
| SCHEMBL30587350 | 0.78 | NPC1 (1.00) | NPC1CYP11B2CYP11B1CYP17A1CYP2A6 | |
| SCHEMBL26260198 | 0.78 | CYP11B2 (0.88) | NPC1CYP11B2CYP11B1CYP17A1CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1092765-A | New tryptamine analogues and preparation method thereof and purposes | SMITHKLINE BEECHAM PLC (GB) | 1994-09-28 | — | — | CN | claimed |
| EP-2903615-B1 | 5-PYRIDIN-3-YL-2,3-DIHYDRO-1H-INDOLE DERIVATIVES AS ALDOSTERONE SYNTHASE (CYP11B2) INHIBITORS FOR THE TREATMENT OF HYPERTENSION | MERCK SHARP & DOHME (US) | 2021-04-07 | — | — | EP | disclosed |
| EP-2903615-B1 | 5-PYRIDIN-3-YL-2,3-DIHYDRO-1H-INDOLE DERIVATIVES AS ALDOSTERONE SYNTHASE (CYP11B2) INHIBITORS FOR THE TREATMENT OF HYPERTENSION | MERCK SHARP & DOHME (US) | 2021-04-07 | — | — | EP | disclosed |
| US-9745282-B2 | Indoline compounds as aldosterone synthase inhibitors | MERCK SHARP & DOHME CORP (US) | 2017-08-29 | — | — | US | disclosed |
| US-9745282-B2 | Indoline compounds as aldosterone synthase inhibitors | MERCK SHARP & DOHME CORP (US) | 2017-08-29 | — | — | US | disclosed |
| US-9745282-B2 | Indoline compounds as aldosterone synthase inhibitors | MERCK SHARP & DOHME CORP (US) | 2017-08-29 | — | — | US | disclosed |
| US-9550750-B2 | Indoline compounds as aldosterone synthase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2017-01-24 | — | — | US | disclosed |
| US-9550750-B2 | Indoline compounds as aldosterone synthase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2017-01-24 | — | — | US | disclosed |
| US-9550750-B2 | Indoline compounds as aldosterone synthase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2017-01-24 | — | — | US | disclosed |
| US-20160304486-A1 | INDOLINE COMPOUNDS AS ALDOSTERONE SYNTHASE INHIBITORS | MERCK SHARP & DOHME LLC | 2016-10-20 | — | — | US | disclosed |
| US-20160304486-A1 | INDOLINE COMPOUNDS AS ALDOSTERONE SYNTHASE INHIBITORS | MERCK SHARP & DOHME LLC | 2016-10-20 | — | — | US | disclosed |
| US-20150225365-A1 | INDOLINE COMPOUNDS AS ALDOSTERONE SYNTHASE INHIBITORS | ELEXOPHARM GMBH (DE) | 2015-08-13 | — | — | US | disclosed |
| US-20150225365-A1 | INDOLINE COMPOUNDS AS ALDOSTERONE SYNTHASE INHIBITORS | ELEXOPHARM GMBH (DE) | 2015-08-13 | — | — | US | disclosed |
| US-20150225365-A1 | INDOLINE COMPOUNDS AS ALDOSTERONE SYNTHASE INHIBITORS | ELEXOPHARM GMBH (DE) | 2015-08-13 | — | — | US | disclosed |
| EP-2903615-A1 | INDOLINE COMPOUNDS AS ALDOSTERONE SYNTHASE INHIBITIORS RELATED APPLICATIONS | Merck Sharp & Dohme Corp. (US) | 2015-08-12 | — | — | EP | disclosed |
| WO-2014055595-A1 | INDOLINE COMPOUNDS AS ALDOSTERONE SYNTHASE INHIBITIORS RELATED APPLICATIONS | MERCK SHARP & DOHME CORP. (US) | 2014-04-10 | — | — | WO | disclosed |
| US-20040236110-A1 | Substituted 3-pyridyl indoles and indazoles as c17,20 lyase inhibitors | BAYER PHARMACEUTICALS CORPORATION | 2004-11-25 | — | — | US | disclosed |
| EP-1432698-A2 | SUBSTITUTED 3-PYRIDYL INDOLES AND INDAZOLES AS C17,20 LYASE INHIBITORS | Bayer Pharmaceuticals Corporation (US) | 2004-06-30 | — | — | EP | disclosed |
| WO-2003027094-A2 | SUBSTITUTED 3-PYRIDYL INDOLES AND INDAZOLES AS C17,20 LYASE INHIBITORS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |
| CN-1092765-A | New tryptamine analogues and preparation method thereof and purposes | SMITHKLINE BEECHAM PLC (GB) | 1994-09-28 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040236110-A1 | Substituted 3-pyridyl indoles and indazoles as c17,20 lyase inhibitors | CYP17A1, IDO1, CYP21A2 | NPC1 2631/4885CYP11B2 53/4885CYP11B1 30/4885 |
| US-20160304486-A1 | INDOLINE COMPOUNDS AS ALDOSTERONE SYNTHASE INHIBITORS | HSD11B1, CYP11B1, CYP11B2 | NPC1 1390/4885CYP11B2 3/4885CYP11B1 2/4885 |
| US-20150225365-A1 | INDOLINE COMPOUNDS AS ALDOSTERONE SYNTHASE INHIBITORS | CYP11B1, CYP11B2, HSD11B1 | NPC1 873/4885CYP11B2 2/4885CYP11B1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.