SCHEMBL6658975

SCHEMBL6658975

Cc1ccc(-c2csc(C(N)=O)n2)cc1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 10/20 0.61
ALDH1A1 P00352 4/20 0.61
L3MBTL1 Q9Y468 1/20 0.61
MAPT P10636 8/20 0.56
NPC1 O15118 6/20 0.56
GFER P55789 1/20 0.56
SMN1; SMN2 Q16637 5/20 0.54
KDM4E B2RXH2 7/20 0.51
GAA P10253 2/20 0.51
CYP3A4 P08684 2/20 0.51
CYP2C9 P11712 2/20 0.51
TDP1 Q9NUW8 2/20 0.51
CYP1A2 P05177 1/20 0.51
CYP2C19 P33261 1/20 0.51
NPSR1 Q6W5P4 1/20 0.51
POLB P06746 2/20 0.50
GSTO1 P78417 1/20 0.50
LTA4H P09960 1/20 0.50
MEN1 O00255 1/20 0.50
KMT2A Q03164 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6687941 0.85 LTA4H (0.61) ALDH1A1MAPTSMN1; SMN2KDM4EGAA
SCHEMBL9829142 0.85 RAB9A (0.55) RAB9AALDH1A1L3MBTL1MAPTNPC1
SCHEMBL7437902 0.83 LMNA (0.61) RAB9AALDH1A1MAPTNPC1SMN1; SMN2
SCHEMBL4640043 0.83 ALOX5 (0.59) RAB9AALDH1A1L3MBTL1MAPTNPC1
SCHEMBL2734989 0.83 RAB9A (0.54) RAB9AALDH1A1L3MBTL1MAPTNPC1
SCHEMBL3088513 0.83 MAP2K3 (0.50) RAB9AALDH1A1MAPTNPC1SMN1; SMN2
SCHEMBL168593 0.83 ALDH1A1 (0.56) RAB9AALDH1A1MAPTNPC1GFER
SCHEMBL3452786 0.83 TP53 (0.51) RAB9AALDH1A1L3MBTL1MAPTNPC1
SCHEMBL9613227 0.83 MAPT (0.51) RAB9AALDH1A1L3MBTL1MAPTNPC1
SCHEMBL7426301 0.83 MEN1 (0.48) RAB9AALDH1A1L3MBTL1MAPTNPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2335700-A1 Hepatitis C virus polymerase inhibitors with a heterobicylic structure BOEHRINGER INGELHEIM (CANADA) LTD. (CA) 2011-06-22 EP disclosed
US-7576079-B2 Viral polymerase inhibitors BOEHRINGER INGELHEIM (CANADA) LTD. (CA) 2009-08-18 US disclosed
EP-1891951-A1 Viral polymerase inhibitors BOEHRINGER INGELHEIM (CANADA) LTD. (CA) 2008-02-27 EP disclosed
EP-1442041-A1 AZABICYCLIC-SUBSTITUTED-HETEROARYL COMPOUNDS FOR THE TREATMENT OF DISEASE PHARMACIA & UPJOHN COMPANY (US) 2004-08-04 EP disclosed
WO-2003040147-A1 AZABICYCLIC-SUBSTITUTED-HETEROARYL COMPOUNDS FOR THE TREATMENT OF DISEASE__________________________________________________________________________________________________________________________ PHARMACIA & UPJOHN COMPANY (US) 2003-05-15 WO disclosed
EP-0506194-B1 4-aryl-thiazole or imidazole derivatives AKZO NOBEL NV (NL) 1996-08-21 EP disclosed
US-5462959-A 4-aryl-imidazole derivatives AKZO N.V. (NL) 1995-10-31 US disclosed
US-5254575-A 4-aryl-thiazole derivatives AKZO N.V. (NL) 1993-10-19 US disclosed
EP-0506194-A1 4-aryl-thiazole or imidazole derivatives Akzo Nobel N.V. (NL) 1992-09-30 EP disclosed