SCHEMBL6659999

SCHEMBL6659999

Cc1cc2c(N)c(F)cc(Cl)c2o1

nearest known ligand 0.33

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
EGFR P00533 1/20 0.33
KDR P35968 1/20 0.33
CA1 P00915 1/20 0.33
CA2 P00918 1/20 0.33
CA9 Q16790 1/20 0.33
ALDH1A1 P00352 1/20 0.30
AHR P35869 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9045894 0.83 ALDH1A1 (0.33) ALDH1A1
SCHEMBL3173335 0.72 ALDH1A1 (0.36) CA1CA2CA9ALDH1A1AHR
SCHEMBL6658600 0.71 GABRA1 (0.33) EGFRKDR
SCHEMBL4113652 0.69 AHR (0.55) ALDH1A1AHR
SCHEMBL21003357 0.67 ALDH1A1 (0.37) ALDH1A1AHR
SCHEMBL6794232 0.67 FBP1 (0.35)
SCHEMBL34469147 0.66 GRIN2D (0.40) CA1CA2CA9ALDH1A1
SCHEMBL3837076 0.66 CA1 (0.39) CA1CA2CA9ALDH1A1
SCHEMBL28158185 0.65 CA1 (0.42) CA1CA2CA9ALDH1A1
SCHEMBL16044935 0.65 CA1 (0.38) CA1CA2CA9ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20040063580-A1 Bicyclic triazolone derivatives and a herbicides containing the same SUMITOMO CHEMICAL TAKEDA AGRO COMPANY, LIMITED (JP) 2004-04-01 US disclosed
US-20040018941-A1 Fused-benzene derivatives of thiouracil, herbicidal and desiccant compositions contaning them ISHIHARA SANGYO KAISHA, LTD. 2004-01-29 US disclosed
WO-2004008859-A1 FUSED-BENZENE DERIVATIVES OF THIOURACIL, HERBICIDAL AND DESICCANT COMPOSITIONS CONTANING THEM ISHIHARA SANGYO KAISHA, LTD. (JP) 2004-01-29 WO disclosed
EP-1333031-A1 BICYCLIC TRIAZOLONE DERIVATIVES AND HERBICIDES CONTAINING THE SAME Sumitomo Chemical Takeda Agro Company, Limited (JP) 2003-08-06 EP disclosed
EP-0476697-B1 Benzofuranyl- and benzothiophenyl substituted uracil derivatives, and their production and use as herbicides SUMITOMO CHEMICAL CO (JP) 1996-03-20 EP disclosed
US-5169431-A Herbicides SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1992-12-08 US disclosed
EP-0476697-A1 Benzofuranyl- and benzothiophenyl substituted uracil derivatives, and their production and use as herbicides SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1992-03-25 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040018941-A1 Fused-benzene derivatives of thiouracil, herbicidal and desiccant compositions contaning them DDT, DPYD, TST EGFR 3436/4885KDR 4415/4885CA1 1667/4885
US-20040063580-A1 Bicyclic triazolone derivatives and a herbicides containing the same WEE1, WEE2, BAK1 EGFR 2670/4885KDR 1271/4885CA1 1472/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.