SCHEMBL66607

SCHEMBL66607

O=CCCc1cccc(C(F)(F)F)c1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TAAR1 Q96RJ0 1/20 0.61
ACP3 P15309 1/20 0.51
MIF P14174 2/20 0.51
DAO P14920 3/20 0.50
IDO1 P14902 2/20 0.50
HTR2A P28223 1/20 0.49
HTR2C P28335 1/20 0.49
HTR2B P41595 1/20 0.49
HDAC1 Q13547 1/20 0.48
HDAC8 Q9BY41 1/20 0.48
MAPT P10636 2/20 0.46
POLB P06746 1/20 0.46
DPP4 P27487 1/20 0.46
KDM4E B2RXH2 1/20 0.45
ALDH1A1 P00352 1/20 0.45
GAA P10253 1/20 0.45
NR3C2 P08235 1/20 0.45
MEN1 O00255 2/20 0.44
KMT2A Q03164 2/20 0.44
LMNA P02545 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Formaldehyde SCHEMBL28263667 0.97 TAAR1 (0.57) TAAR1ACP3MIFDAOIDO1
SCHEMBL18003547 0.90 MAOB (0.50) TAAR1ACP3MIFDAOIDO1
SCHEMBL7870943 0.90 TAAR1 (0.57) TAAR1ACP3MIFDAOIDO1
SCHEMBL19399695 0.88 TAAR1 (0.56) TAAR1ACP3MIFDAOIDO1
SCHEMBL670842 0.88 TAAR1 (0.49) TAAR1ACP3MIFHTR2AHTR2C
Styrene SCHEMBL28262481 0.85 TAAR1 (0.46) TAAR1ACP3MIFDAOIDO1
SCHEMBL39835 0.83 TAAR1 (0.56) TAAR1ACP3MIFDAOIDO1
SCHEMBL13680787 0.82 AGXT (0.56) TAAR1
SCHEMBL10595654 0.82 TAAR1 (0.61) TAAR1ACP3MIFDAOIDO1
SCHEMBL11188459 0.82 TAAR1 (0.61) TAAR1ACP3MIFDAOIDO1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 301 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025099741-A1 PROCESS FOR THE PREPARATION OF NITROSAMINE FREE CINACALCET AND SALTS THEREOF MEGAFINE PHARMA (P) LTD. (IN) 2025-05-15 WO claimed
CN-119350167-A Preparation method of cinacalcet hydrochloride crystal form I 江苏永安制药有限公司 2025-01-24 CN claimed
US-20240318325-A1 ELECTROCHEMICAL HYDROGENOLYSIS OF CARBONYL GROUPS IN ALDEHYDES AND KETONES USING ZINC CATHODES WISCONSIN ALUMNI RESEARCH FOUNDATION 2024-09-26 US claimed
CN-116103256-A Imine reductase mutant and application thereof in synthesis of secondary amine with large steric hindrance 华东理工大学 2023-05-12 CN claimed
CN-109096070-A The production method of m-trifluoromethyl benzenepropanal 中国石油化工股份有限公司 2018-12-28 CN claimed
WO-2016027211-A2 PROCESS FOR THE PREPARATION OF CINACALCET AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS MEHTA API PVT. LTD. (IN) 2016-02-25 WO claimed
US-8921606-B2 Process for cinacalcet hydrochloride HETERO RESEARCH FOUNDATION (IN) 2014-12-30 US claimed
WO-2014178068-A2 AN IMPROVED PROCESS FOR PREPARATION OF N-[1-(1-NAPHTHYL)ETHYL] -3- [3-(TRIFLUOROMETHYL)PHENYL]PROPAN-1-AMINE AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF CADILA HEALTHCARE LIMITED (IN) 2014-11-06 WO claimed
WO-2014016847-A1 A PROCESS FOR THE PREPARATION OF CINACALCET HYDROCHLORIDE AND ITS INTERMEDIATE TYCHE INDUSTRIES LIMITED (IN) 2014-01-30 WO claimed
US-20130178654-A1 PROCESS FOR CINACALCET HYDROCHLORIDE HETERO RESEARCH FOUNDATION (IN) 2013-07-11 US claimed
WO-2012007954-A1 PROCESS FOR CINACALCET HYDROCHLORIDE HETERO RESEARCH FOUNDATION (IN) 2012-01-19 WO claimed
US-20100267988-A1 PROCESSES FOR PREPARING INTERMEDIATE COMPOUNDS USEFUL FOR THE PREPARATION OF CINACALCET MEDICHEM, S.A. (ES) 2010-10-21 US claimed
EP-2170805-A2 METHODS OF SYNTHESIZING CINACALCET AND SALTS THEREOF Amgen Inc. (US) 2010-04-07 EP claimed
US-20100081770-A1 GRAFTED AND FUNCTIONALIZED HIGH 1,4-TRANS POLYBUTADIENE WITH AROMATIC ORGANOSULFUR COMPOUND KOREA KUMHO PETROCHEMICAL CO., LTD. (KR) 2010-04-01 US claimed
EP-2041065-A2 PROCESSES FOR PREPARING CINACALCET HYDROCHLORIDE AND POLYMORPHIC FORMS THEREOF Medichem, S.A. (ES) 2009-04-01 EP claimed
EP-2041056-A2 PROCESSES FOR PREPARING INTERMEDIATE COMPOUNDS USEFUL FOR THE PREPARATION OF CINACALCET Medichem, S.A. (ES) 2009-04-01 EP claimed
WO-2008068625-A9 PROCESSES FOR PREPARING CINACALCET HYDROCHLORIDE AND POLYMORPHIC FORMS THEREOF MEDICHEM SA (ES) 2009-03-26 WO claimed
WO-2009002427-A2 METHODS OF SYNTHESIZING CINACALCET AND SALTS THEREOF AMGEN INC. (US) 2008-12-31 WO claimed
WO-2008068625-A2 PROCESSES FOR PREPARING CINACALCET HYDROCHLORIDE AND POLYMORPHIC FORMS THEREOF MEDICHEM, S.A. (US) 2008-06-12 WO claimed
WO-2008035212-A2 PROCESSES FOR PREPARING INTERMEDIATE COMPOUNDS USEFUL FOR THE PREPARATION OF CINACALCET MEDICHEM, S.A. (US) 2008-03-27 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130178654-A1 PROCESS FOR CINACALCET HYDROCHLORIDE CA4, CA9, CA14 TAAR1 4756/4885ACP3 421/4885MIF 445/4885
US-20100267988-A1 PROCESSES FOR PREPARING INTERMEDIATE COMPOUNDS USEFUL FOR THE PREPARATION OF CINACALCET SI, KRAS, PREP TAAR1 4657/4885ACP3 568/4885MIF 660/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.