SCHEMBL6662930

SCHEMBL6662930

CCc1ccc(C(F)(F)OC(C)c2ccc(OC(F)F)cc2)cc1

nearest known ligand 0.38

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
PPARG P37231 2/20 0.35
PPARA Q07869 2/20 0.35
PTGDR2 Q9Y5Y4 1/20 0.35
RXRA P19793 1/20 0.34
GRIN1 Q05586 1/20 0.34
GRIN2B Q13224 1/20 0.34
LMNA P02545 1/20 0.34
POLB P06746 1/20 0.34
ACACB O00763 1/20 0.33
DAO P14920 1/20 0.33
GAA P10253 1/20 0.33
KMT2A Q03164 2/20 0.32
HTT P42858 1/20 0.32
PKM P14618 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
MEN1 O00255 1/20 0.32
MAPK1 P28482 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6663310 0.90 DAO (0.37) PPARGPPARAPTGDR2LMNAPOLB
SCHEMBL6660727 0.86 PPARA (0.39) PPARAPTGDR2LMNADAOKMT2A
SCHEMBL6664947 0.86 PDE2A (0.44) PPARGPPARAACACBDAO
SCHEMBL6662033 0.84 ALDH1A1 (0.42) PPARGPTGDR2LMNAKMT2AL3MBTL1
SCHEMBL6667003 0.83 LMNA (0.46) LMNAGAAKMT2AHTTL3MBTL1
SCHEMBL6666034 0.82 TSHR (0.34) PPARGPPARALMNAACACBKMT2A
SCHEMBL7730604 0.81 PPARG (0.39) PPARGPPARARXRAGRIN1GRIN2B
SCHEMBL7730882 0.81 PPARG (0.39) PPARGPPARARXRAGRIN1GRIN2B
SCHEMBL6661305 0.81 PDE4A (0.38)
SCHEMBL6661343 0.81 PDE4A (0.30)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0893423-B1 LIQUID CRYSTAL COMPOUNDS HAVING FLUORINATED LINKAGES, LIQUID CRYSTAL COMPOSITIONS, AND LIQUID CRYSTAL DISPLAY DEVICES CHISSO CORP (JP) 2004-09-01 EP disclosed