Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 2/20 | 0.41 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.41 |
| ▸ | PRKAG1 | P54619 | 2/20 | 0.41 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.41 |
| ▸ | PRKAB1 | Q9Y478 | 2/20 | 0.41 |
| ▸ | HTR1A | P08908 | 3/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.36 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.35 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6668468 | 0.94 | KDM5A (0.41) | KDM5AKDM5BPRKAG1PRKAA2PRKAB1 | |
| SCHEMBL6665674 | 0.92 | P2RX3 (0.40) | KDM5AKDM5BPRKAG1PRKAA2PRKAB1 | |
| SCHEMBL6669305 | 0.90 | PRKAG1 (0.41) | KDM5AKDM5BPRKAG1PRKAA2PRKAB1 | |
| SCHEMBL6666674 | 0.88 | KDM4C (0.42) | KDM5AKDM5BGRM2OPRK1KCNH2 | |
| SCHEMBL6666692 | 0.87 | PRKAG1 (0.45) | KDM5AKDM5BPRKAG1PRKAA2PRKAB1 | |
| SCHEMBL6668559 | 0.84 | NNMT (0.41) | KDM5AKDM5BPRKAG1PRKAA2PRKAB1 | |
| SCHEMBL6665427 | 0.83 | NNMT (0.43) | PRKAG1PRKAA2PRKAB1GRM2OPRK1 | |
| SCHEMBL6664538 | 0.81 | NNMT (0.45) | PRKAG1PRKAA2PRKAB1OPRK1KCNH2 | |
| SCHEMBL6663006 | 0.81 | PRKAG1 (0.40) | KDM5AKDM5BPRKAG1PRKAA2PRKAB1 | |
| SCHEMBL6668051 | 0.79 | PTGDR2 (0.43) | PRKAG1PRKAA2PRKAB1OPRK1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004014388-A1 | 6,6-FUSED HETEROARYL DERIVATIVES AS MATRIX METALLOPROTEINASE INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2004-02-19 | — | — | WO | disclosed |