Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.37 |
| ▸ | POLA1 | P09884 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6695928 | 0.83 | POLA1 (0.48) | KCNH2POLA1MEN1KMT2AENPP2 | |
| SCHEMBL6667762 | 0.82 | MEN1 (0.42) | BACE1KDM4EEGFRCDK2KCNH2 | |
| SCHEMBL6668085 | 0.79 | POLA1 (0.42) | KCNH2POLA1RAB9AENPP2 | |
| SCHEMBL6667777 | 0.77 | RAB9A (0.55) | BACE1KDM4EEGFRCDK2KCNH2 | |
| SCHEMBL6667472 | 0.76 | MEN1 (0.41) | KDM4EKCNH2POLA1MEN1KMT2A | |
| SCHEMBL6669289 | 0.76 | NPC1 (0.40) | BACE1KDM4EEGFRCDK2KCNH2 | |
| SCHEMBL6974853 | 0.73 | KCNH2 (0.47) | KCNH2POLA1RAB9AENPP2 | |
| SCHEMBL6666561 | 0.72 | MAPT (0.39) | KDM4EKCNH2POLA1MEN1KMT2A | |
| SCHEMBL6670577 | 0.71 | TSHR (0.47) | KDM4EKCNH2POLA1MAPTENPP2 | |
| SCHEMBL6980565 | 0.70 | KCNH2 (0.44) | KCNH2POLA1ENPP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004019940-A1 | METHOD OF PREVENTING OR TREATING ATHEROSCLEROSIS OR RESTENOSIS | PHARMACIA & UPJOHN COMPANY (US) | 2004-03-11 | — | — | WO | claimed |
| WO-2004019940-A1 | METHOD OF PREVENTING OR TREATING ATHEROSCLEROSIS OR RESTENOSIS | PHARMACIA & UPJOHN COMPANY (US) | 2004-03-11 | — | — | WO | disclosed |