Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 2/20 | 0.44 |
| ▸ | EIF2AK3 | Q9NZJ5 | 2/20 | 0.44 |
| ▸ | HTR2A | P28223 | 12/20 | 0.43 |
| ▸ | HTR2C | P28335 | 12/20 | 0.43 |
| ▸ | HTR2B | P41595 | 11/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 4/20 | 0.39 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6664419 | 0.89 | HTR2A (0.41) | RIPK1EIF2AK3HTR2AHTR2CHTR2B | |
| SCHEMBL6667516 | 0.89 | TP53 (0.42) | RIPK1EIF2AK3HTR2AHTR2CHTR2B | |
| SCHEMBL6637238 | 0.88 | S1PR1 (0.37) | MAPTS1PR1S1PR3 | |
| SCHEMBL6665118 | 0.87 | RIPK1 (0.43) | RIPK1EIF2AK3HTR2AHTR2CHTR2B | |
| Hydrochloric Acid SCHEMBL6666545 | 0.87 | RIPK1 (0.43) | RIPK1EIF2AK3HTR2AHTR2CHTR2B | |
| SCHEMBL6665119 | 0.86 | EIF2AK3 (0.44) | RIPK1EIF2AK3HTR2AHTR2CTP53 | |
| Hydrochloric Acid SCHEMBL6667512 | 0.86 | EIF2AK3 (0.43) | RIPK1EIF2AK3HTR2AHTR2CTP53 | |
| SCHEMBL6804308 | 0.84 | RIPK1 (0.45) | RIPK1EIF2AK3TP53MAPTCYP1A2 | |
| SCHEMBL6669113 | 0.84 | LMNA (0.41) | HTR2AHTR2CHTR2BLMNATP53 | |
| SCHEMBL6666486 | 0.84 | EIF2AK3 (0.41) | RIPK1EIF2AK3TP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1383760-A1 | BIARYLCARBOXAMIDE COMPOUNDS AS APOLIPOPROTEIN B INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2004-01-28 | — | — | EP | disclosed |
| WO-2002090347-A1 | AMIDE COMPOUNDS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-11-14 | — | — | WO | disclosed |