Sugi Predict

Sugi Predict / Compounds / SCHEMBL666790

SCHEMBL666790

SCHEMBL666790

C=CCOC(=O)CCC(N)C(=O)O

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ GRIK1 P39086 3/20 0.48
▸ GRIK2 Q13002 3/20 0.48
▸ SLC1A1 P43005 2/20 0.48
▸ GSR P00390 2/20 0.48
▸ GRM8 O00222 1/20 0.48
▸ GRM6 O15303 1/20 0.48
▸ GRIN2D O15399 1/20 0.48
▸ GRIN3B O60391 1/20 0.48
▸ CYP1A2 P05177 1/20 0.48
▸ GRM5 P41594 1/20 0.48
▸ GRIA1 P42261 1/20 0.48
▸ GRIA2 P42262 1/20 0.48
▸ GRIA3 P42263 1/20 0.48
▸ SLC1A3 P43003 1/20 0.48
▸ SLC1A2 P43004 1/20 0.48
▸ GRIA4 P48058 1/20 0.48
▸ GRIN1 Q05586 1/20 0.48
▸ GRIN2A Q12879 1/20 0.48
▸ GRIK3 Q13003 1/20 0.48
▸ GRIN2B Q13224 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL176228 1.00 GRIK1 (0.48) GRIK1GRIK2SLC1A1GSRGRM8
Trifluoroacetic Acid SCHEMBL30280654 0.91 GRIK1 (0.41) GRIK1GRIK2SLC1A1GSRGRM8
Trifluoroacetic Acid SCHEMBL28528219 0.89 GRIK1 (0.40) GRIK1GRIK2SLC1A1GSRGRM8
SCHEMBL176227 0.87 TSHR (0.47) GRIK1GRIK2SLC1A1GSRGRM8
SCHEMBL3968417 0.87 TSHR (0.47) GRIK1GRIK2SLC1A1GSRGRM8
SCHEMBL176229 0.87 TSHR (0.47) GRIK1GRIK2SLC1A1GSRGRM8
SCHEMBL31714254 0.87 GRIK1 (0.43) GRIK1GRIK2SLC1A1GSRGRM8
SCHEMBL6422885 0.86 TSHR (0.46) GRIK1GRIK2SLC1A1GSRGRM8
SCHEMBL5141195 0.86 TSHR (0.46) GRIK1GRIK2SLC1A1GSRGRM8
SCHEMBL28276401 0.83 TSHR (0.50) BLMKMT2ATSHRTDP1PKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 65 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12569536-B2 Macrocyclic peptides for targeted inhibition of autophagy BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2026-03-10 — — US disclosed
WO-2024235128-A9 ANTIBODY-DRUG CONJUGATE AND PREPARATION METHOD AND USE THEREOF 四川科伦博泰生物医药股份有限公司 2025-06-19 — — WO disclosed
WO-2024235132-A9 COMPOUND HAVING BIOLOGICAL ACTIVITY, AND PREPARATION METHOD THEREFOR AND USE THEREOF 四川科伦博泰生物医药股份有限公司 2025-06-19 — — WO disclosed
WO-2024235128-A1 ANTIBODY-DRUG CONJUGATE AND PREPARATION METHOD AND USE THEREOF 四川科伦博泰生物医药股份有限公司 2024-11-21 — — WO disclosed
WO-2024235132-A1 COMPOUND HAVING BIOLOGICAL ACTIVITY, AND PREPARATION METHOD THEREFOR AND USE THEREOF 四川科伦博泰生物医药股份有限公司 2024-11-21 — — WO disclosed
US-20230040236-A1 Diamine-Linked Melanocortin Receptor-Specific Cyclic Peptides for Ocular Indications PALATIN TECHNOLOGIES, INC. (US) 2023-02-09 — — US disclosed
CN-115515617-A Diamine-linked receptor-specific cyclic peptides 帕拉丁科技公司 2022-12-23 — — CN disclosed
EP-4100040-A1 DIAMINE-LINKED RECEPTOR-SPECIFIC CYCLIC PEPTIDES Palatin Technologies, Inc. (US) 2022-12-14 — — EP disclosed
US-20220169676-A1 INHIBITORS OF GROWTH FACTOR ACTIVATION ENZYMES WASHINGTON UNIVERSITY (US) 2022-06-02 — — US disclosed
US-20220096594-A1 MACROCYCLIC PEPTIDES FOR TARGETED INHIBITION OF AUTOPHAGY BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2022-03-31 — — US disclosed
US-20100035361-A1 TWO HELIX BINDERS GENERAL ELECTRIC COMPANY (US) 2010-02-11 — — US disclosed
US-20090325313-A1 TWO HELIX BINDERS GENERAL ELECTRIC COMPANY (US) 2009-12-31 — — US disclosed
EP-1838749-A1 COATING COMPOSITIONS CONTAINING RHEOLOGY CONTROL AGENTS E.I.Du pont de nemours and company (US) 2007-10-03 — — EP disclosed
WO-2006076715-A1 COATING COMPOSITIONS CONTAINING RHEOLOGY CONTROL AGENTS E.I. DUPONT DE NEMOURS AND COMPANY (US) 2006-07-20 — — WO disclosed
US-20060155021-A1 Coating compositions containing rheology control agents E. I. DU PONT DE NEMOURS AND COMPANY 2006-07-13 — — US disclosed
US-20060155146-A1 Rheology control agents AXALTA COATING SYSTEMS IP CO. LLC (FORMERLY KNOWN AS U.S. COATINGS IP CO. LLC) 2006-07-13 — — US disclosed
US-6040323-A INHIBITING CELL PROLIFERATION OF HUMAN BREAST CANCER CELLS UNIVERSITY OF PITTSBURGH (US) 2000-03-21 — — US disclosed
US-5925660-A ENZYME INHIBITORS FOR PHOSPHATASE UNIVERSITY OF PITTSBURGH (US) 1999-07-20 — — US disclosed
US-5856506-A (OXAZOLYLCARBONYLAMINO)ETHYLAMINO GLUTAMATE DERIVATIVES UNIVERSITY OF PITTSBURGH (US) 1999-01-05 — — US disclosed
US-5700821-A INHIBIT CELL PROLIFERATION UNIVERSITY OF PITTSBURGH (US) 1997-12-23 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12569536-B2 Macrocyclic peptides for targeted inhibition of autophagy ATG7, SQSTM1, VIP GRIK1 3103/4885GRIK2 3234/4885SLC1A1 589/4885
US-20090325313-A1 TWO HELIX BINDERS CNBP, AEBP2, CRYAB GRIK1 4566/4885GRIK2 4334/4885SLC1A1 4281/4885
US-20060155146-A1 Rheology control agents HCRTR1, HCRTR2, REL GRIK1 3008/4885GRIK2 2833/4885SLC1A1 3758/4885
US-20220169676-A1 INHIBITORS OF GROWTH FACTOR ACTIVATION ENZYMES HDGF, MMP7, HGF GRIK1 4057/4885GRIK2 4365/4885SLC1A1 4073/4885
US-20230040236-A1 Diamine-Linked Melanocortin Receptor-Specific Cyclic Peptides for Ocular Indications MC1R, MC3R, MC5R GRIK1 935/4885GRIK2 938/4885SLC1A1 256/4885
US-20100035361-A1 TWO HELIX BINDERS CRYAB, AEBP2, CNBP GRIK1 4608/4885GRIK2 4379/4885SLC1A1 4362/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.