Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.35 |
| ▸ | CFD | P00746 | 1/20 | 0.34 |
| ▸ | F11 | P03951 | 1/20 | 0.34 |
| ▸ | TPSB2 | P20231 | 1/20 | 0.34 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ANPEP | P15144 | 1/20 | 0.33 |
| ▸ | ENPEP | Q07075 | 1/20 | 0.33 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3930203 | 0.78 | HTR2C (0.42) | KDM4ELMNAHIF1AALOX5CFD | |
| SCHEMBL1026693 | 0.78 | ALDH1A1 (0.42) | KDM4ELMNACYP3A4CYP2C9PTGS1 | |
| SCHEMBL1555330 | 0.76 | ALDH1A1 (0.50) | LMNACYP3A4CYP2C9SMN1; SMN2MEN1 | |
| SCHEMBL1025144 | 0.74 | SCN2A (0.39) | LMNACYP3A4CYP2C9SMN1; SMN2MEN1 | |
| SCHEMBL9995385 | 0.74 | CYP3A4 (0.35) | LMNACYP3A4CYP2C9SMN1; SMN2MEN1 | |
| SCHEMBL17728900 | 0.74 | HTR3E (0.44) | LMNAMAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL7379122 | 0.74 | RXRA (0.45) | KDM4ELMNACYP3A4CYP2C9MAPT | |
| SCHEMBL67323 | 0.74 | MTNR1A (0.44) | KDM4ELMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL7034982 | 0.74 | KMT2A (0.47) | CYP3A4CYP2C9MAPTSMN1; SMN2MEN1 | |
| SCHEMBL666092 | 0.74 | LOXL2 (0.43) | LMNACFDCYP3A4CYP2C9SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120046269-A1 | Novel Amino Azaheterocyclic Carboxamides | MERCK PATENT GMBH (DE) | 2012-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120046269-A1 | Novel Amino Azaheterocyclic Carboxamides | AZI2, MKI67, MYC | KDM4E 272/4885LMNA 3629/4885HIF1A 463/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.