Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1F | P30939 | 14/20 | 0.47 |
| ▸ | HTR1D | P28221 | 10/20 | 0.47 |
| ▸ | HTR1B | P28222 | 8/20 | 0.47 |
| ▸ | HTR1A | P08908 | 5/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | HTR1E | P28566 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.43 |
| ▸ | TDO2 | P48775 | 1/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.40 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.40 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6722245 | 0.85 | HTR1F (0.51) | HTR1FHTR1DHTR1BHTR1AHTR2A | |
| SCHEMBL6722057 | 0.80 | HTR1F (0.47) | HTR1FHTR1DHTR1BHTR1AHTR2A | |
| SCHEMBL9938051 | 0.79 | MTNR1A (0.51) | HTR1FHTR1DHTR1BGABRA1GABRB2 | |
| SCHEMBL6726534 | 0.78 | HTR1F (0.49) | HTR1FHTR1DHTR1BHTR1A | |
| SCHEMBL6724813 | 0.76 | HTR1A (0.55) | HTR1FHTR1DHTR1BHTR1AHTR2A | |
| SCHEMBL6724677 | 0.74 | HTR1F (0.42) | HTR1FHTR1DHTR1BHTR1AHTR2A | |
| SCHEMBL622321 | 0.71 | GABRA1 (0.54) | GABRA1GABRB2GABRB1GABRA3 | |
| SCHEMBL6389885 | 0.71 | GABRA1 (0.54) | GABRA1GABRB2GABRB1GABRA3 | |
| SCHEMBL6726471 | 0.71 | HTR1A (0.52) | HTR1FHTR1DHTR1BHTR1AHTR2A | |
| SCHEMBL25193742 | 0.71 | GABRA1 (0.46) | GABRA1GABRB2GABRB1GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1453831-A1 | 1H-PYRROLO(3,2-B)PYRIDINE-3-CARBOXYLIC ACID AMIDES | Neurogen Corporation (US) | 2004-09-08 | — | — | EP | disclosed |
| US-6673811-B1 | TREATMENT OF ANXIETY, DEPRESSION, SLEEP DISORDER, ATTENTION DEFICIT DISORDER, ALZHEIMER'S DEMENTIA, OR SHORT-TERM MEMORY LOSS | NEUROGEN CORPORATION | 2004-01-06 | — | — | US | disclosed |
| WO-2003044018-A1 | 1H-PYRROLO[3,2-B]PYRIDINE-3-CARBOXYLIC ACID AMIDES | NEUROGEN CORPORATION (US) | 2003-05-30 | — | — | WO | disclosed |