Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1F | P30939 | 12/20 | 0.42 |
| ▸ | HTR1D | P28221 | 10/20 | 0.42 |
| ▸ | HTR1B | P28222 | 10/20 | 0.42 |
| ▸ | PRKAG1 | P54619 | 3/20 | 0.37 |
| ▸ | PRKAA1 | Q13131 | 3/20 | 0.37 |
| ▸ | PRKAB1 | Q9Y478 | 3/20 | 0.37 |
| ▸ | PRKAB2 | O43741 | 2/20 | 0.37 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.37 |
| ▸ | PRKAG3 | Q9UGI9 | 2/20 | 0.37 |
| ▸ | PRKAG2 | Q9UGJ0 | 2/20 | 0.37 |
| ▸ | HTR1A | P08908 | 7/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6722057 | 0.92 | HTR1F (0.47) | HTR1FHTR1DHTR1BPRKAG1PRKAA1 | |
| SCHEMBL6722245 | 0.88 | HTR1F (0.51) | HTR1FHTR1DHTR1BHTR1AHTR2A | |
| SCHEMBL6667683 | 0.78 | MTNR1A (0.53) | HTR1FHTR1DHTR1BPRKAG1PRKAA1 | |
| SCHEMBL30267364 | 0.78 | MTNR1A (0.53) | HTR1FHTR1DHTR1BPRKAG1PRKAA1 | |
| SCHEMBL6728722 | 0.78 | MAPT (0.44) | PRKAG1PRKAA1PRKAB1PRKAB2PRKAA2 | |
| SCHEMBL6724521 | 0.75 | PRKAB2 (0.46) | HTR1FHTR1DHTR1BPRKAG1PRKAA1 | |
| SCHEMBL6671364 | 0.75 | ALDH1A1 (0.40) | PRKAG1PRKAA1PRKAB1PRKAB2PRKAA2 | |
| SCHEMBL6724740 | 0.75 | PRKAB2 (0.52) | HTR1FHTR1DHTR1BPRKAG1PRKAA1 | |
| SCHEMBL6670992 | 0.74 | HTR1F (0.47) | HTR1FHTR1DHTR1BHTR1AHTR2A | |
| SCHEMBL6726471 | 0.73 | HTR1A (0.52) | HTR1FHTR1DHTR1BHTR1AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6673811-B1 | TREATMENT OF ANXIETY, DEPRESSION, SLEEP DISORDER, ATTENTION DEFICIT DISORDER, ALZHEIMER'S DEMENTIA, OR SHORT-TERM MEMORY LOSS | NEUROGEN CORPORATION | 2004-01-06 | — | — | US | claimed |
| US-6673811-B1 | TREATMENT OF ANXIETY, DEPRESSION, SLEEP DISORDER, ATTENTION DEFICIT DISORDER, ALZHEIMER'S DEMENTIA, OR SHORT-TERM MEMORY LOSS | NEUROGEN CORPORATION | 2004-01-06 | — | — | US | disclosed |