Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.39 |
| ▸ | PRKAG1 | P54619 | 5/20 | 0.39 |
| ▸ | PRKAA1 | Q13131 | 5/20 | 0.39 |
| ▸ | PRKAB1 | Q9Y478 | 5/20 | 0.39 |
| ▸ | F7 | P08709 | 1/20 | 0.38 |
| ▸ | F3 | P13726 | 1/20 | 0.38 |
| ▸ | PRKAB2 | O43741 | 3/20 | 0.38 |
| ▸ | PRKAA2 | P54646 | 3/20 | 0.38 |
| ▸ | PRKAG3 | Q9UGI9 | 3/20 | 0.38 |
| ▸ | PRKAG2 | Q9UGJ0 | 3/20 | 0.38 |
| ▸ | JAK2 | O60674 | 2/20 | 0.37 |
| ▸ | JAK1 | P23458 | 2/20 | 0.37 |
| ▸ | JAK3 | P52333 | 2/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 3/20 | 0.35 |
| ▸ | PIM2 | Q9P1W9 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30267364 | 0.84 | MTNR1A (0.53) | ALDH1A1MTNR1AMTNR1BPRKAG1PRKAA1 | |
| SCHEMBL6667683 | 0.84 | MTNR1A (0.53) | ALDH1A1MTNR1AMTNR1BPRKAG1PRKAA1 | |
| SCHEMBL6728722 | 0.80 | MAPT (0.44) | ALDH1A1MTNR1AMTNR1BPRKAG1PRKAA1 | |
| SCHEMBL6734102 | 0.77 | PRKAG1 (0.46) | ALDH1A1MTNR1AMTNR1BPRKAG1PRKAA1 | |
| SCHEMBL14655309 | 0.76 | JAK3 (0.55) | JAK2JAK1JAK3 | |
| SCHEMBL22050698 | 0.75 | F7 (0.44) | PRKAG1PRKAA1PRKAB1F7F3 | |
| SCHEMBL6722084 | 0.75 | PIM1 (0.48) | ALDH1A1MTNR1AMTNR1BPIM1PIM2 | |
| SCHEMBL6724677 | 0.75 | HTR1F (0.42) | MTNR1AMTNR1BPRKAG1PRKAA1PRKAB1 | |
| SCHEMBL5606528 | 0.74 | MTNR1A (0.50) | ALDH1A1MTNR1AMTNR1BPRKAG1PRKAA1 | |
| SCHEMBL6722059 | 0.74 | ALDH1A1 (0.43) | ALDH1A1MTNR1AMTNR1BPOLBTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1453831-A1 | 1H-PYRROLO(3,2-B)PYRIDINE-3-CARBOXYLIC ACID AMIDES | Neurogen Corporation (US) | 2004-09-08 | — | — | EP | claimed |
| US-6673811-B1 | TREATMENT OF ANXIETY, DEPRESSION, SLEEP DISORDER, ATTENTION DEFICIT DISORDER, ALZHEIMER'S DEMENTIA, OR SHORT-TERM MEMORY LOSS | NEUROGEN CORPORATION | 2004-01-06 | — | — | US | claimed |
| WO-2003044018-A1 | 1H-PYRROLO[3,2-B]PYRIDINE-3-CARBOXYLIC ACID AMIDES | NEUROGEN CORPORATION (US) | 2003-05-30 | — | — | WO | claimed |
| US-6673811-B1 | TREATMENT OF ANXIETY, DEPRESSION, SLEEP DISORDER, ATTENTION DEFICIT DISORDER, ALZHEIMER'S DEMENTIA, OR SHORT-TERM MEMORY LOSS | NEUROGEN CORPORATION | 2004-01-06 | — | — | US | disclosed |