Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 5/20 | 0.42 |
| ▸ | CES1 | P23141 | 5/20 | 0.42 |
| ▸ | CES2 | O00748 | 2/20 | 0.42 |
| ▸ | CA2 | P00918 | 3/20 | 0.41 |
| ▸ | GCLC | P48506 | 1/20 | 0.38 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6906378 | 0.79 | ACE2 (0.47) | FAAHCES1CES2CA2GCLC | |
| SCHEMBL9067216 | 0.78 | NOS2 (0.54) | FAAHCES1CES2CA2GCLC | |
| Hydrochloric Acid SCHEMBL9359667 | 0.76 | ACE2 (0.49) | FAAHCES1CES2CA2GPR84 | |
| SCHEMBL6646261 | 0.76 | NOS2 (0.53) | FAAHCES1CES2CA2GCLC | |
| SCHEMBL7364147 | 0.75 | GCLC (0.53) | FAAHCES1CES2CA2GCLC | |
| SCHEMBL9324909 | 0.71 | FAAH (0.50) | FAAHCES1CES2CA2GPR84 | |
| SCHEMBL20448523 | 0.71 | GPR84 (0.56) | CA2GPR84FFAR1MAPT | |
| Acetic Acid SCHEMBL9621822 | 0.71 | CA2 (0.56) | FAAHCES1CES2CA2GPR84 | |
| SCHEMBL1195000 | 0.70 | FAAH (0.58) | FAAHCES1CES2CA2GPR84 | |
| SCHEMBL17688537 | 0.70 | GPR84 (0.59) | CA2GPR84FFAR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0950059-B1 | CYCLIC SULFONE DERIVATIVES | PFIZER (US) | 2004-08-04 | — | — | EP | disclosed |
| US-6077864-A | USEFUL IN THE TREATMENT OF ARTHRITIS, CANCER, TISSUE ULCERATION, MACULAR DEGENERATION, RESTENOSIS, PERIODONTAL DISEASE, EPIDERMOLYSIS BULLOSA, SCLERITIS | PFIZER INC. (US) | 2000-06-20 | — | — | US | disclosed |
| EP-0950059-A1 | CYCLIC SULFONE DERIVATIVES | PFIZER INC. (US) | 1999-10-20 | — | — | EP | disclosed |
| US-5883131-A | Cyclic sulfone derivatives | PFIZER INC. (US) | 1999-03-16 | — | — | US | disclosed |
| WO-1998030566-A1 | CYCLIC SULFONE DERIVATIVES | PFIZER INC. (US) | 1998-07-16 | — | — | WO | disclosed |
| EP-0818442-A2 | Cyclic sulphone derivatives as inhibitors of metalloproteinases and of the production of tumour necrosis factor | PFIZER INC. (US) | 1998-01-14 | — | — | EP | disclosed |