Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FABP4 | P15090 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | HTR3A | P46098 | 4/20 | 0.52 |
| ▸ | PLK1 | P53350 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | HTR6 | P50406 | 1/20 | 0.48 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.47 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | TNF | P01375 | 1/20 | 0.42 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6674814 | 0.85 | AKR1C3 (0.62) | FABP4LMNASMN1; SMN2HTR3APLK1 | |
| SCHEMBL17176310 | 0.85 | SMN1; SMN2 (0.70) | LMNASMN1; SMN2HTR3APLK1MEN1 | |
| SCHEMBL6649721 | 0.83 | BRD4 (0.44) | FABP4LMNASMN1; SMN2HTR3APLK1 | |
| SCHEMBL17170611 | 0.81 | ALDH1A1 (0.56) | FABP4LMNASMN1; SMN2HTR3APLK1 | |
| SCHEMBL4926276 | 0.81 | LMNA (0.74) | FABP4LMNASMN1; SMN2PLK1MEN1 | |
| SCHEMBL19068172 | 0.81 | KMT2A (0.57) | LMNASMN1; SMN2HTR3APLK1MEN1 | |
| SCHEMBL30689046 | 0.80 | ALOX5 (0.65) | FABP4LMNASMN1; SMN2PLK1MEN1 | |
| SCHEMBL22638205 | 0.80 | ALOX5 (0.65) | FABP4LMNASMN1; SMN2PLK1MEN1 | |
| Acetic Acid SCHEMBL6652044 | 0.79 | BRD4 (0.44) | FABP4LMNASMN1; SMN2HTR3APLK1 | |
| SCHEMBL19068164 | 0.79 | HTR3A (0.48) | FABP4LMNASMN1; SMN2HTR3APLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1478624-A1 | CHEMICAL COMPOUNDS | AstraZeneca AB (SE) | 2004-11-24 | — | — | EP | disclosed |
| WO-2003068743-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2003-08-21 | — | — | WO | disclosed |