Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | HTR3A | P46098 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | HTR6 | P50406 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | PLK1 | P53350 | 1/20 | 0.47 |
| ▸ | MITF | O75030 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.45 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.45 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19068164 | 0.85 | HTR3A (0.48) | KMT2AL3MBTL1HTR3ALMNASMN1; SMN2 | |
| SCHEMBL27622290 | 0.84 | LMNA (0.72) | KMT2AL3MBTL1LMNASMN1; SMN2HTR6 | |
| SCHEMBL17176310 | 0.83 | SMN1; SMN2 (0.70) | KMT2AL3MBTL1HTR3ALMNASMN1; SMN2 | |
| SCHEMBL6674814 | 0.83 | AKR1C3 (0.62) | KMT2AHTR3ALMNASMN1; SMN2HTR6 | |
| SCHEMBL6672345 | 0.81 | FABP4 (0.55) | KMT2AHTR3ALMNASMN1; SMN2HTR6 | |
| SCHEMBL19969859 | 0.80 | HTR3A (0.54) | HTR3AHTR6CNR1 | |
| SCHEMBL17170611 | 0.79 | ALDH1A1 (0.56) | KMT2AL3MBTL1HTR3ALMNASMN1; SMN2 | |
| SCHEMBL4106159 | 0.78 | KMT2A (0.73) | KMT2AL3MBTL1HTR3ALMNASMN1; SMN2 | |
| SCHEMBL16979075 | 0.76 | KMT2A (0.75) | KMT2AL3MBTL1LMNASMN1; SMN2TSHR | |
| SCHEMBL22289917 | 0.75 | HTR3A (0.56) | KMT2AHTR3ALMNASMN1; SMN2HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9695195-B2 | 5-HT3 receptor antagonists | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2017-07-04 | — | — | US | disclosed |