Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATG4B | Q9Y4P1 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | CASP3 | P42574 | 4/20 | 0.51 |
| ▸ | SENP8 | Q96LD8 | 4/20 | 0.51 |
| ▸ | SENP7 | Q9BQF6 | 4/20 | 0.51 |
| ▸ | SENP6 | Q9GZR1 | 4/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.51 |
| ▸ | POLB | P06746 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | GSK3A | P49840 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.45 |
| ▸ | HIPK4 | Q8NE63 | 1/20 | 0.45 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.45 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7038371 | 0.80 | CASP3 (0.59) | ATG4BALDH1A1CASP3SENP8SENP7 | |
| SCHEMBL6676799 | 0.80 | HDAC1 (0.50) | ALDH1A1MEN1KMT2ALMNAEPHX1 | |
| SCHEMBL5227781 | 0.72 | MAPT (0.40) | ALDH1A1CASP3SENP8SENP7SENP6 | |
| SCHEMBL10133046 | 0.71 | MGLL (0.65) | ALDH1A1MEN1KMT2ALMNAEPHX1 | |
| SCHEMBL3757985 | 0.71 | CYP2C9 (0.60) | ALDH1A1MEN1MAPTKMT2AADAMTS5 | |
| SCHEMBL28570074 | 0.71 | POLB (0.57) | ALDH1A1POLBMEN1KMT2ANPC1 | |
| SCHEMBL18541826 | 0.71 | ATG4B (1.00) | ATG4BCDK2GSK3AGSK3BDYRK1A | |
| SCHEMBL18529258 | 0.69 | ATG4B (0.64) | ATG4BALDH1A1CASP3SENP8SENP7 | |
| SCHEMBL599832 | 0.69 | CYP2C9 (0.67) | MEN1KMT2AADAMTS5MGLLNPC1 | |
| SCHEMBL3274691 | 0.69 | FAAH (0.64) | ALDH1A1POLBKMT2AADAMTS5LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1465613-A2 | COMBINATION OF MTP INHIBITORS OR APOB SECRETION INHIBITORS WITH FIBRATES FOR USE AS DRUGS | Boehringer Ingelheim Pharma GmbH & Co. KG (DE) | 2004-10-13 | — | — | EP | disclosed |
| WO-2003057205-A2 | COMBINATION OF MTP INHIBITORS OR APOB SECRETION INHIBITORS WITH FIBRATES FOR USE AS DRUGS | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2003-07-17 | — | — | WO | disclosed |
| WO-2003004020-A1 | HETEROARYL CARBOXYLIC ACID AMIDES, THE PRODUCTION THEREOF AND THE USE OF THE SAME AS INHIBITORS OF THE MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN (MTP) | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2003-01-16 | — | — | WO | disclosed |