Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GLS | O94925 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | BTK | Q06187 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 2/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.34 |
| ▸ | BMX | P51813 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6674712 | 0.89 | ALDH1A1 (0.36) | LMNAPOLBMAPTALDH1A1HPGD | |
| SCHEMBL6676282 | 0.80 | KCNA5 (0.41) | LMNAPOLBHPGDALOX12KMT2A | |
| SCHEMBL6676214 | 0.79 | MAPT (0.44) | LMNAMAPTALDH1A1HPGDALOX12 | |
| SCHEMBL6681404 | 0.78 | ESR1 (0.41) | GLSALDH1A1HTR2CSLC6A4HSD17B10 | |
| SCHEMBL6679750 | 0.78 | NQO2 (0.50) | LMNAPOLBALDH1A1HPGDKMT2A | |
| SCHEMBL6680966 | 0.77 | ALDH1A1 (0.36) | LMNAPOLBGLSALDH1A1HTR2C | |
| SCHEMBL7247906 | 0.77 | LMNA (0.34) | LMNAPOLBGLSMAPTALDH1A1 | |
| SCHEMBL27494018 | 0.77 | CRHBP (0.40) | LMNAMAPTALDH1A1HPGDALOX12 | |
| SCHEMBL7238099 | 0.76 | GLS (0.46) | POLBGLSALDH1A1KMT2AGAA | |
| SCHEMBL6678098 | 0.76 | GPR35 (0.39) | ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0798292-B1 | ANILINE DERIVATIVES HAVING NITROGEN MONOXIDE SYNTHASE INHIBITORY ACTIVITY | CHUGAI SEIYAKUKABUSHIKI KAISHA (JP) | 2004-11-03 | — | — | EP | disclosed |
| US-6534546-B1 | Guanidine- or isothioureido-N-derived anilines; brain, nervous system, and neurodegenerative disorders | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2003-03-18 | — | — | US | disclosed |
| EP-0798292-A1 | ANILINE DERIVATIVES HAVING NITROGEN MONOXIDE SYNTHASE INHIBITORY ACTIVITY | Chugai Seiyaku Kabushiki Kaisha (JP) | 1997-10-01 | — | — | EP | disclosed |