Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.39 |
| ▸ | REN | P00797 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.34 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.34 |
| ▸ | PDK3 | Q15120 | 2/20 | 0.34 |
| ▸ | PDK4 | Q16654 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6674712 | 0.87 | ALDH1A1 (0.36) | ALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL6675971 | 0.85 | CACNA1C (0.43) | GPR35RENMEN1KMT2AMAPK1 | |
| SCHEMBL6678270 | 0.85 | LMNA (0.35) | ALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL27496002 | 0.82 | GPR35 (0.41) | GPR35MEN1KMT2AMAPK1ALDH1A1 | |
| SCHEMBL6676278 | 0.81 | REN (0.37) | GPR35RENMEN1KMT2AMAPK1 | |
| SCHEMBL6675968 | 0.81 | GPR35 (0.39) | GPR35RENMEN1KMT2AMAPK1 | |
| SCHEMBL7242001 | 0.80 | GPR35 (0.38) | GPR35RENMEN1KMT2AMAPK1 | |
| SCHEMBL7242006 | 0.79 | GPR35 (0.38) | GPR35RENMEN1KMT2AMAPK1 | |
| SCHEMBL6678436 | 0.79 | ALDH1A1 (0.40) | KMT2AALDH1A1 | |
| SCHEMBL6678068 | 0.78 | REN (0.36) | RENL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0798292-B1 | ANILINE DERIVATIVES HAVING NITROGEN MONOXIDE SYNTHASE INHIBITORY ACTIVITY | CHUGAI SEIYAKUKABUSHIKI KAISHA (JP) | 2004-11-03 | — | — | EP | disclosed |
| US-6534546-B1 | Guanidine- or isothioureido-N-derived anilines; brain, nervous system, and neurodegenerative disorders | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2003-03-18 | — | — | US | disclosed |
| EP-0798292-A1 | ANILINE DERIVATIVES HAVING NITROGEN MONOXIDE SYNTHASE INHIBITORY ACTIVITY | Chugai Seiyaku Kabushiki Kaisha (JP) | 1997-10-01 | — | — | EP | disclosed |