Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | CCR5 | P51681 | 1/20 | 0.39 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
| ▸ | AGER | Q15109 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6681828 | 0.99 | ENPP2 (0.43) | ENPP2L3MBTL1PTGDR2SIGMAR1HTR2C | |
| SCHEMBL8893633 | 0.97 | L3MBTL1 (0.45) | ENPP2L3MBTL1PTGDR2SIGMAR1HTR2C | |
| SCHEMBL6687688 | 0.96 | L3MBTL1 (0.43) | ENPP2L3MBTL1PTGDR2SIGMAR1HTR2C | |
| SCHEMBL6675898 | 0.88 | ALDH1A1 (0.43) | ENPP2L3MBTL1HTR2CSLC6A4HSD11B1 | |
| SCHEMBL5727402 | 0.86 | CCR5 (0.41) | L3MBTL1SLC6A4HSD11B1CCR5 | |
| SCHEMBL18154489 | 0.86 | L3MBTL1 (0.41) | L3MBTL1SIGMAR1HSD11B1CCR5 | |
| SCHEMBL18163696 | 0.85 | CCR5 (0.47) | L3MBTL1SIGMAR1HSD11B1CCR5 | |
| SCHEMBL18154352 | 0.84 | HSD11B1 (0.48) | HSD11B1CCR5 | |
| SCHEMBL22285161 | 0.84 | ENPP2 (0.57) | ENPP2L3MBTL1PTGDR2SIGMAR1CCR5 | |
| SCHEMBL190556 | 0.84 | ENPP2 (0.57) | ENPP2L3MBTL1PTGDR2SIGMAR1CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0813544-B1 | BRADYKININ ANTAGONIST PEPTIDES INCORPORATING N-SUBSTITUTED GLYCINES | CORTECH INC (US) | 2004-10-27 | — | — | EP | disclosed |
| EP-0813544-A4 | — | — | 1998-01-07 | — | — | EP | disclosed |
| EP-0813544-A1 | BRADYKININ ANTAGONIST PEPTIDES INCORPORATING N-SUBSTITUTED GLYCINES | CORTECH, INC. (US) | 1997-12-29 | — | — | EP | disclosed |
| WO-1995024422-A1 | BRADYKININ ANTAGONIST PEPTIDES INCORPORATING N-SUBSTITUTED GLYCINES | CORTECH, INC. (US) | 1995-09-14 | — | — | WO | disclosed |