SCHEMBL8893633

SCHEMBL8893633

CC(C)(C)OC(=O)N(CC(=O)OCc1ccccc1)C1CCCCC1

nearest known ligand 0.45

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 3/20 0.45
ENPP2 Q13822 1/20 0.45
SIGMAR1 Q99720 1/20 0.42
HTR2C P28335 1/20 0.41
SLC6A4 P31645 1/20 0.41
HSD11B1 P28845 1/20 0.41
PTGDR2 Q9Y5Y4 1/20 0.41
AGER Q15109 3/20 0.40
ALDH1A1 P00352 1/20 0.40
MAPK1 P28482 1/20 0.40
TSHR P16473 1/20 0.40
MTNR1A P48039 1/20 0.40
CTSL P07711 1/20 0.40
CCR5 P51681 1/20 0.40
CCKBR P32239 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6687688 0.99 L3MBTL1 (0.43) L3MBTL1ENPP2SIGMAR1HTR2CSLC6A4
SCHEMBL6680503 0.97 ENPP2 (0.45) L3MBTL1ENPP2SIGMAR1HTR2CSLC6A4
SCHEMBL6681828 0.95 ENPP2 (0.43) L3MBTL1ENPP2SIGMAR1HTR2CSLC6A4
SCHEMBL6675898 0.91 ALDH1A1 (0.43) L3MBTL1ENPP2HTR2CSLC6A4HSD11B1
SCHEMBL18154489 0.89 L3MBTL1 (0.41) L3MBTL1SIGMAR1HSD11B1ALDH1A1MAPK1
SCHEMBL5727402 0.89 CCR5 (0.41) L3MBTL1SLC6A4HSD11B1CCR5
SCHEMBL18163696 0.88 CCR5 (0.47) L3MBTL1SIGMAR1HSD11B1CCR5
SCHEMBL18154352 0.87 HSD11B1 (0.48) HSD11B1CCR5
SCHEMBL18154101 0.86 KLK7 (0.42) L3MBTL1HSD11B1ALDH1A1MAPK1CTSL
SCHEMBL5725684 0.86 OPRM1 (0.51) SIGMAR1HTR2CHSD11B1CCR5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 48 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260091024-A1 PRODRUGS OF RILUZOLE AND THEIR METHOD OF USE BIOHAVEN THERAPEUTICS LTD (US) 2026-04-02 US disclosed
US-20260041673-A1 PRODRUGS OF RILUZOLE AND THEIR METHOD OF USE BIOHAVEN THERAPEUTICS LTD (US) 2026-02-12 US disclosed
US-12472165-B2 Riluzole prodrugs and their use BIOHAVEN THERAPEUTICS LTD. (VG) 2025-11-18 US disclosed
US-20250332148-A1 RILUZOLE PRODRUGS AND THEIR USE BIOHAVEN THERAPEUTICS LTD (US) 2025-10-30 US disclosed
US-12295942-B2 Riluzole prodrugs and their use BIOHAVEN THERAPEUTICS LTD. (VG) 2025-05-13 US disclosed
US-12213965-B2 Riluzole prodrugs and their use BIOHAVEN THERAPEUTICS LTD. (VG) 2025-02-04 US disclosed
US-12005047-B2 Riluzole prodrugs and their use BIOHAVEN THERAPEUTICS LTD. (US) 2024-06-11 US disclosed
US-12005046-B2 Riluzole prodrugs and their use BIOHAVEN THERAPEUTICS LTD. (US) 2024-06-11 US disclosed
US-20240091205-A1 PRODRUGS OF RILUZOLE AND THEIR METHOD OF USE BEETLEJUICE SA LLC, AS PURCHASER AGENT 2024-03-21 US disclosed
US-11911369-B2 Prodrugs of riluzole and their method of use BIOHAVEN THERAPEUTICS LTD. (VG) 2024-02-27 US disclosed
US-20180037557-A1 PRODRUGS RILUZOLE AND THEIR METHOD OF USE BEETLEJUICE SA LLC, AS PURCHASER AGENT 2018-02-08 US disclosed
US-20180037557-A1 PRODRUGS RILUZOLE AND THEIR METHOD OF USE BEETLEJUICE SA LLC, AS PURCHASER AGENT 2018-02-08 US disclosed
US-20180037557-A1 PRODRUGS RILUZOLE AND THEIR METHOD OF USE BEETLEJUICE SA LLC, AS PURCHASER AGENT 2018-02-08 US disclosed
US-20180036290-A1 RILUZOLE PRODRUGS AND THEIR USE BEETLEJUICE SA LLC, AS PURCHASER AGENT 2018-02-08 US disclosed
US-20180036290-A1 RILUZOLE PRODRUGS AND THEIR USE BEETLEJUICE SA LLC, AS PURCHASER AGENT 2018-02-08 US disclosed
US-20180036290-A1 RILUZOLE PRODRUGS AND THEIR USE BEETLEJUICE SA LLC, AS PURCHASER AGENT 2018-02-08 US disclosed
WO-2016140878-A9 PRODRUGS RILUZOLE AND THEIR METHOD OF USE BIOHAVEN PHARMACEUTICAL HOLDING COMPANY LTD. (US) 2016-10-20 WO disclosed
CN-1150206-C Bradykinin antagonist peptides containing N-substituted glycines 2004-05-19 CN disclosed
US-5700779-A ALLEVIATING PAIN, ASTHMA, INFLAMMATION, CEREBRAL EDEMA, CARDIOVASCULAR DYSFUNCTION CORTECH, INC. (US) 1997-12-23 US disclosed
CN-1148393-A Bradykinin antagonist peptides incorporating N-substituted glycines CORTECH INC (US) 1997-04-23 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (12 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180036290-A1 RILUZOLE PRODRUGS AND THEIR USE APEH, ALDH1A2, UGT1A9 L3MBTL1 449/4885ENPP2 3192/4885SIGMAR1 457/4885
US-20260091024-A1 PRODRUGS OF RILUZOLE AND THEIR METHOD OF USE IL6ST, GFRA3, GFRA1 L3MBTL1 338/4885ENPP2 4486/4885SIGMAR1 68/4885
US-12005046-B2 Riluzole prodrugs and their use APEH, ALDH1A2, UGT1A9 L3MBTL1 449/4885ENPP2 3192/4885SIGMAR1 457/4885
US-11911369-B2 Prodrugs of riluzole and their method of use APEH, UGT1A9, ALDH3A1 L3MBTL1 743/4885ENPP2 2906/4885SIGMAR1 331/4885
US-12005047-B2 Riluzole prodrugs and their use APEH, ALDH1A2, UGT1A9 L3MBTL1 449/4885ENPP2 3192/4885SIGMAR1 457/4885
US-20260041673-A1 PRODRUGS OF RILUZOLE AND THEIR METHOD OF USE GFRA3, IL6ST, GFRA1 L3MBTL1 342/4885ENPP2 4508/4885SIGMAR1 71/4885
US-12472165-B2 Riluzole prodrugs and their use APEH, ALDH1A2, UGT1A9 L3MBTL1 449/4885ENPP2 3192/4885SIGMAR1 457/4885
US-12295942-B2 Riluzole prodrugs and their use APEH, ALDH1A2, UGT1A9 L3MBTL1 449/4885ENPP2 3192/4885SIGMAR1 457/4885
US-20180037557-A1 PRODRUGS RILUZOLE AND THEIR METHOD OF USE APEH, CYP2C9, ALDH1A2 L3MBTL1 831/4885ENPP2 2898/4885SIGMAR1 489/4885
US-20240091205-A1 PRODRUGS OF RILUZOLE AND THEIR METHOD OF USE APEH, UGT1A9, ALDH3A1 L3MBTL1 743/4885ENPP2 2906/4885SIGMAR1 331/4885
US-20250332148-A1 RILUZOLE PRODRUGS AND THEIR USE APEH, ALDH1A2, UGT1A9 L3MBTL1 449/4885ENPP2 3192/4885SIGMAR1 457/4885
US-12213965-B2 Riluzole prodrugs and their use APEH, ALDH1A2, UGT1A9 L3MBTL1 449/4885ENPP2 3192/4885SIGMAR1 457/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.