Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 9/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1302652 | 0.85 | ALDH1A1 (0.40) | ALDH1A1L3MBTL1MAPTTDP1MEN1 | |
| SCHEMBL6390480 | 0.85 | ALDH1A1 (0.41) | ALDH1A1L3MBTL1MAPTTDP1MEN1 | |
| SCHEMBL6643777 | 0.83 | ALDH1A1 (0.41) | ALDH1A1L3MBTL1MAPTTDP1MEN1 | |
| SCHEMBL1303526 | 0.81 | GAA (0.47) | ALDH1A1L3MBTL1MAPTTDP1KDM4E | |
| SCHEMBL8399454 | 0.79 | KDM4E (0.52) | ALDH1A1L3MBTL1MAPTTDP1MEN1 | |
| SCHEMBL15674547 | 0.79 | PKM (0.49) | ALDH1A1L3MBTL1MAPTTDP1MEN1 | |
| SCHEMBL6809786 | 0.78 | RAB9A (0.46) | MAPTMEN1KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL4220098 | 0.78 | ALDH1A1 (0.47) | ALDH1A1L3MBTL1MAPTTDP1MEN1 | |
| SCHEMBL6683403 | 0.78 | ALDH1A1 (0.45) | ALDH1A1L3MBTL1TDP1KMT2ASMN1; SMN2 | |
| SCHEMBL21382605 | 0.77 | L3MBTL1 (0.42) | ALDH1A1L3MBTL1MAPTTDP1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004062661-A1 | 2-‘5-(5-CARBAMIMIDOYL-1H-HETEROARYL)-6-HYDROXYBIPHENYL-3-YL!- CARBOXYLIC ACID DERIVATIVES AS FACTOR VIIA INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2004-07-29 | — | — | WO | disclosed |