Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.36 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.36 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6688710 | 0.89 | POLB (0.43) | MAPTGAARAB9AMEN1KMT2A | |
| SCHEMBL6687560 | 0.88 | MAPT (0.38) | MAPTGAAMAPK1ALDH1A1MEN1 | |
| SCHEMBL6689081 | 0.83 | TOP2B (0.36) | CA12CA1CA2CA9 | |
| SCHEMBL6687217 | 0.78 | PARP1 (0.42) | MEN1KMT2A | |
| SCHEMBL4800097 | 0.73 | CTSK (0.42) | MAPTGAARAB9AMAPK1HSD17B10 | |
| SCHEMBL10798884 | 0.68 | GAA (0.70) | MAPTGAARAB9AMAPK1HSD17B10 | |
| SCHEMBL29939726 | 0.68 | MAPT (0.59) | MAPTGAARAB9AFFAR1ALDH1A1 | |
| SCHEMBL5404160 | 0.67 | EPHX2 (0.46) | MAPTGAARAB9AALDH1A1NPC1 | |
| SCHEMBL5409955 | 0.66 | EPHX2 (0.47) | MAPTGAARAB9AALDH1A1NPC1 | |
| SCHEMBL9372673 | 0.66 | MAPT (0.52) | MAPTGAARAB9AALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004084843-A2 | INHIBITORS OF CATHEPSIN S | IRM LLC (BM) | 2004-10-07 | — | — | WO | disclosed |