Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD274 | Q9NZQ7 | 11/20 | 0.53 |
| ▸ | PDCD1 | Q15116 | 8/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | DHODH | Q02127 | 2/20 | 0.39 |
| ▸ | CTSV | O60911 | 1/20 | 0.38 |
| ▸ | CTSL | P07711 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6690764 | 0.82 | PDCD1 (0.46) | CD274PDCD1KMT2AMEN1GAA | |
| SCHEMBL6706928 | 0.78 | PDCD1 (0.51) | CD274PDCD1CTSVCTSLRAB9A | |
| SCHEMBL6254676 | 0.77 | PDCD1 (0.41) | CD274PDCD1KMT2AMEN1GAA | |
| SCHEMBL6254681 | 0.77 | PDCD1 (0.41) | CD274PDCD1KMT2AMEN1GAA | |
| SCHEMBL6693470 | 0.75 | LMNA (0.44) | CD274PDCD1KMT2AMEN1GAA | |
| SCHEMBL6685589 | 0.75 | SCN9A (0.50) | KMT2AMEN1 | |
| SCHEMBL6685594 | 0.75 | SCN9A (0.50) | KMT2AMEN1 | |
| SCHEMBL6233564 | 0.72 | LMNA (0.53) | KMT2AMEN1SMN1; SMN2DHODHRAB9A | |
| SCHEMBL6271865 | 0.70 | SMN1; SMN2 (0.47) | CD274PDCD1KMT2AMEN1GAA | |
| SCHEMBL28405145 | 0.69 | CD274 (1.00) | CD274PDCD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004087125-A1 | AMINO ACID DERIVATIVES AS INHIBITORS OF MAMMALIAN SODIUM CHANNELS | IONIX PHARMACEUTICALS LIMITED (GB) | 2004-10-14 | — | — | WO | disclosed |