Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | PKM | P14618 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3053691 | 0.85 | LMNA (0.54) | POLBALDH1A1LMNAPKMKMT2A | |
| SCHEMBL6926084 | 0.84 | POLB (0.56) | POLBALDH1A1LMNAPKMKMT2A | |
| SCHEMBL6695770 | 0.83 | ALDH1A1 (0.56) | POLBALDH1A1LMNAPKMSMN1; SMN2 | |
| SCHEMBL6925065 | 0.83 | ALDH1A1 (0.57) | POLBALDH1A1LMNAPKMGAA | |
| SCHEMBL6827869 | 0.80 | ALDH1A1 (0.57) | POLBALDH1A1LMNAPKMGAA | |
| SCHEMBL6705341 | 0.80 | ALDH1A1 (0.50) | POLBALDH1A1LMNAPKMKMT2A | |
| SCHEMBL6925711 | 0.77 | PKM (0.46) | POLBALDH1A1LMNAPKMKMT2A | |
| SCHEMBL6923729 | 0.76 | ALDH1A1 (0.52) | POLBALDH1A1LMNAPKMGAA | |
| SCHEMBL3069441 | 0.74 | TSHR (0.60) | ALDH1A1LMNAKMT2AGAASMN1; SMN2 | |
| SCHEMBL3077251 | 0.73 | ALDH1A1 (0.57) | POLBALDH1A1LMNAPKMGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004074438-A2 | CCR8 ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-09-02 | — | — | WO | claimed |
| WO-2004074438-A2 | CCR8 ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-09-02 | — | — | WO | disclosed |