Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 6/20 | 0.39 |
| ▸ | GSK3A | P49840 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | BLM | P54132 | 2/20 | 0.35 |
| ▸ | GMNN | O75496 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | THPO | P40225 | 1/20 | 0.35 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | FAAH | O00519 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | WRN | Q14191 | 1/20 | 0.30 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.30 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7604431 | 0.74 | MGLL (0.33) | MGLLGSK3AGSK3BFAAH | |
| SCHEMBL819470 | 0.69 | — | — | |
| SCHEMBL905713 | 0.69 | ELANE (0.38) | MGLLGSK3AGSK3BALDH1A1MAPT | |
| SCHEMBL18650107 | 0.69 | MGLL (0.36) | MGLLGSK3AGSK3BALDH1A1MAPT | |
| SCHEMBL1709061 | 0.68 | PARL (0.33) | — | |
| SCHEMBL7139394 | 0.67 | MGLL (0.42) | MGLLGSK3AGSK3BALDH1A1MAPT | |
| SCHEMBL10666060 | 0.67 | MGLL (0.42) | MGLLGSK3AGSK3BALDH1A1MAPT | |
| SCHEMBL7850554 | 0.67 | GAA (0.47) | ALDH1A1MAPTLMNANPSR1CYP1A2 | |
| SCHEMBL20931037 | 0.65 | BRD4 (0.36) | — | |
| SCHEMBL2111704 | 0.65 | MGLL (0.35) | MGLLGSK3AGSK3BALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11746086-B2 | Non-aggregating heptamethine cyanine fluorophores for in vivo imaging | THE USA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2023-09-05 | — | — | US | disclosed |
| US-11746086-B2 | Non-aggregating heptamethine cyanine fluorophores for in vivo imaging | THE USA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2023-09-05 | — | — | US | disclosed |
| US-9771321-B2 | Small molecules that covalently modify transthyretin | THE SCRIPPS RESEARCH INSTITUTE (US) | 2017-09-26 | — | — | US | disclosed |
| US-9771321-B2 | Small molecules that covalently modify transthyretin | THE SCRIPPS RESEARCH INSTITUTE (US) | 2017-09-26 | — | — | US | disclosed |
| US-20170190660-A9 | Small Molecules That Covalently Modify Transthyretin | KELLY JEFFERY W (US) | 2017-07-06 | — | — | US | disclosed |
| US-20140336254-A1 | Small Molecules That Covalently Modify Transthyretin | KELLY JEFFERY W (US) | 2014-11-13 | — | — | US | disclosed |
| US-8865390-B2 | Patterning process and resist composition | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 2014-10-21 | — | — | US | disclosed |
| US-8865390-B2 | Patterning process and resist composition | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 2014-10-21 | — | — | US | disclosed |
| US-8703815-B2 | Small molecules that covalently modify transthyretin | THE SCRIPPS RESEARCH INSTITUTE (US) | 2014-04-22 | — | — | US | disclosed |
| US-20130071788-A1 | PATTERNING PROCESS AND RESIST COMPOSITION | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 2013-03-21 | — | — | US | disclosed |
| US-20130071788-A1 | PATTERNING PROCESS AND RESIST COMPOSITION | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 2013-03-21 | — | — | US | disclosed |
| US-20120270938-A1 | SMALL MOLECULES THAT COVALENTLY MODIFY TRANSTHYRETIN | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2012-10-25 | — | — | US | disclosed |
| US-6737217-B2 | SUCH AS POLY(MALEIC ANHYDRIDE/HEXAFLUOROBUTYL-5-NORBORNENE-2-CARBOXYLATE/2,6-DIFLUORO-1 -METHYLBENZYLACRYLATE) ; FOR PRODUCTION OF SEMICONDUCTORS/INTEGRATED CIRCUITS; PHOTOLITHOGRAPHY | HYNIX SEMICONDUCTOR INC. (KR) | 2004-05-18 | — | — | US | disclosed |
| US-6653047-B2 | Monomers such as 2,6-difluoro-1-methylbenzyl 5-norbornene-2-carboxylate; etching resistance, heat resistance and adhesiveness, and can be developed in aqueous tetramethylammonium hydroxide; semiconductors | HYNIX SEMICONDUCTOR INC (KR) | 2003-11-25 | — | — | US | disclosed |
| US-20030022103-A1 | Photoresist monomers containing fluorine-substituted benzylcarboxylate and photoresist polymers comprising the same | HYNIX SEMICONDUCTOR INC. (KR) | 2003-01-30 | — | — | US | disclosed |
| US-20030017412-A1 | Photoresist monomers containing fluorine-substituted benzylcarboxylate and photoresist polymers comprising the same | HYNIX SEMICONDUCTOR INC. (KR) | 2003-01-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140336254-A1 | Small Molecules That Covalently Modify Transthyretin | TTR, TTPA, APOB | MGLL 2481/4885GSK3A 3975/4885GSK3B 3892/4885 |
| US-20170190660-A9 | Small Molecules That Covalently Modify Transthyretin | TTR, TTPA, APOB | MGLL 2481/4885GSK3A 3975/4885GSK3B 3892/4885 |
| US-11746086-B2 | Non-aggregating heptamethine cyanine fluorophores for in vivo imaging | CNDP2, MSN, CHAT | MGLL 4036/4885GSK3A 4423/4885GSK3B 4409/4885 |
| US-20120270938-A1 | SMALL MOLECULES THAT COVALENTLY MODIFY TRANSTHYRETIN | TTR, TTPA, APOB | MGLL 2481/4885GSK3A 3975/4885GSK3B 3892/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.