SCHEMBL6690784

SCHEMBL6690784

Cc1cccc(Cn2cc(-c3ccco3)cn2)c1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA2A P29274 4/20 0.50
ADORA1 P30542 4/20 0.50
ALDH1A1 P00352 4/20 0.48
PKM P14618 1/20 0.48
KDM4E B2RXH2 1/20 0.46
POLB P06746 1/20 0.46
GAA P10253 1/20 0.46
ADORA2B P29275 2/20 0.45
ADORA3 P0DMS8 1/20 0.45
L3MBTL1 Q9Y468 2/20 0.44
SCD5 Q86SK9 6/20 0.44
NPC1 O15118 1/20 0.44
RAB9A P51151 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
CLK4 Q9HAZ1 1/20 0.43
SCD O00767 3/20 0.43
TDP1 Q9NUW8 1/20 0.43
HCRTR1 O43613 1/20 0.41
HCRTR2 O43614 1/20 0.41
PRMT6 Q96LA8 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7096885 0.85 ADORA2A (0.52) ADORA2AADORA1ADORA2BADORA3L3MBTL1
SCHEMBL6693887 0.84 MEN1 (0.60) ADORA2AADORA1ALDH1A1PKMKDM4E
SCHEMBL7004006 0.84 L3MBTL1 (0.64) ADORA2AADORA1ALDH1A1KDM4EPOLB
SCHEMBL7096746 0.80 ADORA2A (0.54) ADORA2AADORA1ALDH1A1PKMKDM4E
SCHEMBL7098488 0.79 L3MBTL1 (0.57) ADORA2AADORA1ALDH1A1PKMKDM4E
SCHEMBL25583758 0.77 ALDH1A1 (0.54) ADORA2AADORA1ALDH1A1POLBADORA2B
SCHEMBL7097845 0.76 ADORA2A (0.43) ADORA2AADORA1ALDH1A1PKMKDM4E
SCHEMBL6691423 0.76 ADORA2A (0.48) ADORA2AADORA1ALDH1A1PKMKDM4E
SCHEMBL15344194 0.74 L3MBTL1 (0.71) ADORA2AADORA1ALDH1A1PKMGAA
SCHEMBL1703331 0.74 MEN1 (0.68) ADORA2AADORA1ALDH1A1PKMADORA2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-2004517861-A 2004-06-17 JP claimed
EP-1349552-A1 PYRAZOLO 3,4-D]PYRIMIDINE DERIVATIVES AND THEIR USE AS PURINERGIC RECEPTOR ANTAGONISTS VERNALIS RESEARCH LIMITED (GB) 2003-10-08 EP claimed
WO-2002055082-A1 PYRAZOLO[3,4-D]PYRIMIDINE DERIVATIVES AND THEIR USE AS PURINERGIC RECEPTOR ANTAGONISTS VERNALIS RESEARCH LIMITED (GB) 2002-07-18 WO claimed
EP-1349552-A1 PYRAZOLO 3,4-D]PYRIMIDINE DERIVATIVES AND THEIR USE AS PURINERGIC RECEPTOR ANTAGONISTS VERNALIS RESEARCH LIMITED (GB) 2003-10-08 EP disclosed
WO-2002055082-A1 PYRAZOLO[3,4-D]PYRIMIDINE DERIVATIVES AND THEIR USE AS PURINERGIC RECEPTOR ANTAGONISTS VERNALIS RESEARCH LIMITED (GB) 2002-07-18 WO disclosed