Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.57 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.45 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | PKM | P14618 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.42 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.42 |
| ▸ | SCD5 | Q86SK9 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | SCD | O00767 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | BCR | P11274 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7004006 | 0.86 | L3MBTL1 (0.64) | L3MBTL1ADORA2AADORA1ALDH1A1KDM4E | |
| SCHEMBL6690784 | 0.79 | ADORA2A (0.50) | L3MBTL1ADORA2AADORA1ADORA3ADORA2B | |
| SCHEMBL7096885 | 0.79 | ADORA2A (0.52) | L3MBTL1ADORA2AADORA1ADORA3ADORA2B | |
| SCHEMBL7097845 | 0.79 | ADORA2A (0.43) | L3MBTL1ADORA2AADORA1ADORA3ADORA2B | |
| SCHEMBL6693887 | 0.76 | MEN1 (0.60) | L3MBTL1ADORA2AADORA1ADORA3ADORA2B | |
| SCHEMBL6691423 | 0.75 | ADORA2A (0.48) | L3MBTL1ADORA2AADORA1ADORA3ADORA2B | |
| SCHEMBL7096746 | 0.74 | ADORA2A (0.54) | ADORA2AADORA1ADORA3ADORA2BALDH1A1 | |
| SCHEMBL12068737 | 0.73 | L3MBTL1 (0.56) | L3MBTL1ALDH1A1PKMKDM4EKDM5B | |
| SCHEMBL7096791 | 0.73 | ADORA2A (0.48) | L3MBTL1ADORA2AADORA1ADORA3ADORA2B | |
| SCHEMBL7092539 | 0.73 | ADORA2A (0.50) | L3MBTL1ADORA2AADORA1ADORA3ADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1349552-A1 | PYRAZOLO 3,4-D]PYRIMIDINE DERIVATIVES AND THEIR USE AS PURINERGIC RECEPTOR ANTAGONISTS | VERNALIS RESEARCH LIMITED (GB) | 2003-10-08 | — | — | EP | disclosed |
| WO-2002055082-A1 | PYRAZOLO[3,4-D]PYRIMIDINE DERIVATIVES AND THEIR USE AS PURINERGIC RECEPTOR ANTAGONISTS | VERNALIS RESEARCH LIMITED (GB) | 2002-07-18 | — | — | WO | disclosed |