SCHEMBL6690974

SCHEMBL6690974

COc1nc(N)ccc1Cl

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CRHBP P24387 1/20 0.41
CRHR2 Q13324 1/20 0.41
MCHR1 Q99705 1/20 0.40
NCF1 P14598 1/20 0.40
GRM4 Q14833 1/20 0.40
DYRK1A Q13627 2/20 0.39
NOS3 P29474 1/20 0.37
NOS1 P29475 1/20 0.37
NOS2 P35228 1/20 0.37
HSP90AA1 P07900 3/20 0.37
HSP90AB1 P08238 3/20 0.37
GSK3A P49840 1/20 0.36
GSK3B P49841 1/20 0.36
CLK4 Q9HAZ1 1/20 0.36
MEN1 O00255 4/20 0.35
KMT2A Q03164 4/20 0.35
NPC1 O15118 3/20 0.35
MAPT P10636 3/20 0.35
RAB9A P51151 2/20 0.35
KDM4E B2RXH2 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30531704 1.00 CRHBP (0.41) CRHBPCRHR2MCHR1NCF1GRM4
SCHEMBL30503540 0.82 CRHBP (0.59) CRHBPCRHR2GRM4HSP90AA1HSP90AB1
SCHEMBL19407671 0.82 CRHBP (0.59) CRHBPCRHR2GRM4HSP90AA1HSP90AB1
SCHEMBL31661310 0.78 MCHR1 (0.45) CRHBPCRHR2MCHR1NOS3NOS1
SCHEMBL20606860 0.78 L3MBTL1 (0.39) CRHBPCRHR2MCHR1NCF1NOS3
SCHEMBL13746013 0.77 NCF1 (0.42) MCHR1NCF1DYRK1ANOS3NOS1
SCHEMBL13865706 0.76 GRM4 (0.41) CRHBPCRHR2GRM4MEN1KMT2A
SCHEMBL29586509 0.76 POLB (0.50) CRHBPCRHR2GRM4KMT2ANPC1
SCHEMBL15544743 0.76 NOS2 (0.54) MCHR1NCF1DYRK1ANOS3NOS1
SCHEMBL359862 0.76 MCHR1 (0.50) MCHR1NCF1NOS3NOS1NOS2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024220236-A2 HYDROXYLAMINE-BASED BCR-ABL1 INHIBITORS FOR TREATMENT OF CANCER UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) 2024-10-24 WO disclosed
WO-2023014908-A1 LPAR1 ANTAGONISTS AND USES THEREOF Pipeline Therapeutics, Inc. (US) 2023-02-09 WO disclosed
WO-2013164245-A1 PLANT GROWTH REGULATING COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2013-11-07 WO disclosed
WO-2004081000-A1 QUINAZOLINE DERIVATIVES ASTRAZENECA AB (SE) 2004-09-23 WO disclosed
WO-2004069250-A1 3-CYANO-QUINOLINE DERIVATIVES AS NON-RECEPTOR TYROSINE KINASE INHIBITORS ASTRAZENECA AB (SE) 2004-08-19 WO disclosed