Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 2/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 9/20 | 0.46 |
| ▸ | EBP | Q15125 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19130231 | 1.00 | KDM1A (0.47) | KDM1ASIGMAR1EBPMEN1KMT2A | |
| SCHEMBL19124508 | 0.95 | SIGMAR1 (0.47) | KDM1ASIGMAR1EBPMEN1KMT2A | |
| SCHEMBL19130781 | 0.95 | SIGMAR1 (0.47) | KDM1ASIGMAR1EBPMEN1KMT2A | |
| SCHEMBL19130238 | 0.89 | SIGMAR1 (0.43) | KDM1ASIGMAR1MAPK1LMNA | |
| SCHEMBL15894662 | 0.89 | SIGMAR1 (0.43) | KDM1ASIGMAR1MAPK1LMNA | |
| SCHEMBL17295965 | 0.89 | SIGMAR1 (0.43) | KDM1ASIGMAR1MAPK1LMNA | |
| SCHEMBL1333907 | 0.82 | KDM1A (0.47) | KDM1ASIGMAR1EBPMEN1KMT2A | |
| SCHEMBL7960703 | 0.82 | KDM1A (0.44) | KDM1ASIGMAR1EBPMEN1KMT2A | |
| SCHEMBL15891588 | 0.81 | CASP6 (0.45) | KDM1ASIGMAR1EBPMEN1KMT2A | |
| SCHEMBL4420303 | 0.79 | SIGMAR1 (0.49) | KDM1ASIGMAR1MEN1KMT2ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10196338-B2 | Chiral diamine compounds for the preparation of chiral alcohols and chiral amines | UNIVERSITY COLLEGE DUBLIN (IE) | 2019-02-05 | — | — | US | disclosed |
| US-20170204036-A1 | CHIRAL DIAMINE COMPOUNDS FOR THE PREPARATION OF CHIRAL ALCOHOLS AND CHIRAL AMINES | UNIVERSITY COLLEGE DUBLIN (IE) | 2017-07-20 | — | — | US | disclosed |
| US-9211287-B2 | Pyrido[4,3-b]indole and pyrido[3,4-b]indole derivatives and methods of use | MEDIVATION TECHNOLOGIES, INC. (US) | 2015-12-15 | — | — | US | disclosed |
| US-20150258075-A1 | PYRIDO[4,3-B]INDOLE AND PYRIDO[3,4-B]INDOLE DERIVATIVES AND METHODS OF USE | MEDIVATION TECHNOLOGIES, INC. (US) | 2015-09-17 | — | — | US | disclosed |
| US-9035056-B2 | Pyrido[4,3-b]indole and pyrido[3,4-b]indole derivatives and methods of use | MEDIVATION TECHNOLOGIES, INC. (US) | 2015-05-19 | — | — | US | disclosed |
| US-20140206711-A1 | PYRIDO[4,3-b]INDOLE AND PYRIDO[3,4-b]INDOLE DERIVATIVES AND METHODS OF USE | MEDIVATION TECHNOLOGIES, INC. (US) | 2014-07-24 | — | — | US | disclosed |
| EP-1633758-B1 | IMIDAZOTHIAZOLES AND IMIDAZOXAZOLE DERIVATIVES AS INHIBITORS OF P38 | ARQULE INC (US) | 2011-11-23 | — | — | EP | disclosed |
| EP-2251343-A1 | IMIDAZOTHIAZOLES AS P38-KINASE-INHIBITORS | ARQULE, INC. (US) | 2010-11-17 | — | — | EP | disclosed |
| WO-2004071389-A2 | NON-STEROIDAL INFALMMATION INHIBITORS | GLAXO GROUP LIMITED (GB) | 2004-08-26 | — | — | WO | disclosed |
| US-6660884-B2 | Catalyst promote synthesis of tertiary alcohols with enantioselectivity; Bicyclo(2.2.1)heptane-1-methane sulfonamide-N,N'-(1S,2S)-1,2-cyclohexanediylbis(2-hydroxy-7,7-dimethyl) -(1R,1'R,2S,2'S,4S,4'S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | 2003-12-09 | — | — | US | disclosed |
| US-20030191345-A1 | CATALYSTS, METHODS FOR MAKING SAID CATALYSTS, AND METHODS FOR MAKING CHIRAL COMPOUNDS WITH HIGH ENANTIOSELECTIVITY | TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE | 2003-10-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150258075-A1 | PYRIDO[4,3-B]INDOLE AND PYRIDO[3,4-B]INDOLE DERIVATIVES AND METHODS OF USE | HTR1B, HTR2B, HTR2A | KDM1A 4034/4885SIGMAR1 1331/4885EBP 1738/4885 |
| US-10196338-B2 | Chiral diamine compounds for the preparation of chiral alcohols and chiral amines | ADH1C, ADH1A, ADH5 | KDM1A 2595/4885SIGMAR1 490/4885EBP 1876/4885 |
| US-20030191345-A1 | CATALYSTS, METHODS FOR MAKING SAID CATALYSTS, AND METHODS FOR MAKING CHIRAL COMPOUNDS WITH HIGH ENANTIOSELECTIVITY | COASY, HMGCR, ALKBH1 | KDM1A 854/4885SIGMAR1 2837/4885EBP 964/4885 |
| US-20140206711-A1 | PYRIDO[4,3-b]INDOLE AND PYRIDO[3,4-b]INDOLE DERIVATIVES AND METHODS OF USE | HTR1B, HTR2B, HTR2A | KDM1A 4034/4885SIGMAR1 1331/4885EBP 1738/4885 |
| US-20170204036-A1 | CHIRAL DIAMINE COMPOUNDS FOR THE PREPARATION OF CHIRAL ALCOHOLS AND CHIRAL AMINES | ADH1C, ADH1A, ADH5 | KDM1A 2341/4885SIGMAR1 457/4885EBP 1482/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.