Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | ALPL | P05186 | 1/20 | 0.34 |
| ▸ | ALPI | P09923 | 1/20 | 0.34 |
| ▸ | ALPG | P10696 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | CA4 | P22748 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6859267 | 0.78 | KDM4E (0.46) | CYP2C9SMN1; SMN2LMNAEPHX1KDM4E | |
| SCHEMBL22366261 | 0.71 | LMNA (0.39) | CYP2C9SMN1; SMN2LMNAEPHX1KDM4E | |
| SCHEMBL667874 | 0.71 | EPHX1 (0.44) | CYP2C9SMN1; SMN2LMNAEPHX1KDM4E | |
| SCHEMBL22689218 | 0.70 | FFAR3 (0.32) | CA4 | |
| SCHEMBL13967130 | 0.70 | RAB9A (0.36) | CYP2C9SMN1; SMN2LMNAEPHX1KDM4E | |
| SCHEMBL13645773 | 0.70 | RAB9A (0.36) | CYP2C9SMN1; SMN2LMNAEPHX1KDM4E | |
| Lithium Ion SCHEMBL1991851 | 0.69 | EPHX1 (0.30) | EPHX1 | |
| SCHEMBL6289243 | 0.69 | EPHX1 (0.37) | CYP2C9SMN1; SMN2LMNAEPHX1KDM4E | |
| SCHEMBL7752566 | 0.69 | EPHX1 (0.37) | CYP2C9SMN1; SMN2LMNAEPHX1KDM4E | |
| SCHEMBL11469749 | 0.69 | ALDH1A1 (0.37) | CYP2C9SMN1; SMN2LMNAEPHX1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8642797-B2 | Amidate precursors for depositing metal containing films | AIR PRODUCTS AND CHEMICALS, INC. (US) | 2014-02-04 | — | — | US | disclosed |
| US-20120045589-A1 | Amidate Precursors For Depositing Metal Containing Films | AIR PRODUCTS AND CHEMICALS, INC. (US) | 2012-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120045589-A1 | Amidate Precursors For Depositing Metal Containing Films | TERT, METTL3, TAF5 | CYP2C9 3906/4885SMN1; SMN2 2947/4885LMNA 1228/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.