Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 4/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | KDM2B | Q8NHM5 | 4/20 | 0.43 |
| ▸ | PARP1 | P09874 | 2/20 | 0.42 |
| ▸ | MGLL | Q99685 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6691901 | 0.86 | CCR2 (0.47) | CCR2KCNH2HRH3KDM2BPARP1 | |
| SCHEMBL6692575 | 0.81 | LMNA (0.45) | PARP1HPGDIP6K1LMNATP53 | |
| SCHEMBL6688446 | 0.80 | PARP1 (0.46) | HRH3KDM2BPARP1HPGDTP53 | |
| SCHEMBL6695959 | 0.75 | LMNA (0.47) | OPRK1PARP1LMNATP53TSHR | |
| SCHEMBL30309577 | 0.74 | PIK3CA (0.49) | CCR2KCNH2HRH3LMNATP53 | |
| SCHEMBL22163997 | 0.74 | PIK3CA (0.49) | CCR2KCNH2HRH3LMNATP53 | |
| SCHEMBL3377190 | 0.74 | NAMPT (0.47) | OPRK1PARP1LMNA | |
| SCHEMBL6688452 | 0.73 | PARP1 (0.48) | HRH3PARP1HPGDTP53TSHR | |
| SCHEMBL5323972 | 0.72 | MAPK14 (0.55) | — | |
| SCHEMBL21230031 | 0.72 | ACHE (0.48) | CCR2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004074438-A2 | CCR8 ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-09-02 | — | — | WO | claimed |