Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | CHKA | P35790 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | HRH2 | P25021 | 2/20 | 0.41 |
| ▸ | HRH1 | P35367 | 2/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 2/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6692578 | 0.87 | LMNA (0.47) | LMNATP53ALOX15TSHRKMT2A | |
| SCHEMBL6692232 | 0.85 | KMT2A (0.49) | KMT2AHPGDALDH1A1HTTDRD2 | |
| SCHEMBL6692009 | 0.84 | CA12 (0.46) | CNR2HRH2HRH1PARP1CA12 | |
| SCHEMBL6703688 | 0.82 | PARP1 (0.49) | LMNATSHRKMT2ASIGMAR1CNR2 | |
| SCHEMBL6691898 | 0.81 | CCR2 (0.46) | LMNATP53ALOX15TSHRPARP1 | |
| SCHEMBL6687434 | 0.81 | HPGD (0.44) | TSHRKMT2ACHKACNR2PARP1 | |
| SCHEMBL6697097 | 0.80 | PARP1 (0.42) | LMNATSHRKMT2ACHKACNR2 | |
| SCHEMBL6692407 | 0.79 | KMT2A (0.54) | LMNATSHRKMT2AHPGDALDH1A1 | |
| SCHEMBL11938971 | 0.78 | DRD2 (0.54) | KMT2ASIGMAR1HRH2HRH1HPGD | |
| SCHEMBL6692746 | 0.78 | CNR2 (0.51) | LMNATSHRKMT2ASIGMAR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004074438-A2 | CCR8 ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-09-02 | — | — | WO | claimed |