Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 5/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.47 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.45 |
| ▸ | PARP1 | P09874 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | RORC | P51449 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6691898 | 0.86 | CCR2 (0.46) | CCR2KCNH2KDM2BPARP1LMNA | |
| SCHEMBL30309577 | 0.85 | PIK3CA (0.49) | CCR2KCNH2LMNATP53TSHR | |
| SCHEMBL22163997 | 0.85 | PIK3CA (0.49) | CCR2KCNH2LMNATP53TSHR | |
| SCHEMBL21230031 | 0.83 | ACHE (0.48) | CCR2KCNH2PIK3CAMTOR | |
| SCHEMBL22767193 | 0.81 | HPGD (0.55) | LMNATP53ALOX15TSHRMAPT | |
| SCHEMBL6692578 | 0.81 | LMNA (0.47) | PARP1LMNATP53ALOX15TSHR | |
| SCHEMBL22767344 | 0.79 | HPGD (0.58) | LMNATP53ALOX15TSHRHSD11B1 | |
| SCHEMBL15688131 | 0.79 | ALDH1A1 (0.56) | LMNATP53ALOX15TSHRMAPT | |
| SCHEMBL20750391 | 0.78 | PIK3CA (0.44) | TSHRMAPTPIK3CAMTOR | |
| SCHEMBL6695963 | 0.74 | CHRM2 (0.47) | KDM2BPARP1LMNATP53TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004074438-A2 | CCR8 ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-09-02 | — | — | WO | claimed |