Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 5/20 | 0.38 |
| ▸ | ADRB1 | P08588 | 5/20 | 0.38 |
| ▸ | ADRB3 | P13945 | 5/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.37 |
| ▸ | CTSS | P25774 | 2/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.36 |
| ▸ | CTSB | P07858 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
| ▸ | PTPRB | P23467 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | XBP1 | P17861 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6664868 | 0.93 | CTSK (0.41) | ATMKLK5CTSKALDH1A1 | |
| SCHEMBL6663482 | 0.93 | KLK5 (0.41) | ATMKLK5CTSSCTSLCTSB | |
| SCHEMBL6666961 | 0.92 | ALDH1A1 (0.39) | ATMKLK5CTSSCTSLCTSB | |
| SCHEMBL6668504 | 0.92 | ALDH1A1 (0.39) | ATMKLK5CTSSCTSLCTSB | |
| SCHEMBL6666632 | 0.91 | ALDH1A1 (0.40) | ATMKLK5CTSSCTSLCTSB | |
| SCHEMBL9378904 | 0.86 | CTSS (0.41) | ATMKLK5CTSSCTSLCTSB | |
| SCHEMBL9379291 | 0.85 | ATM (0.39) | ATMKLK5CTSSCTSLCTSB | |
| SCHEMBL9373974 | 0.85 | PTPRB (0.39) | ATMKLK5CTSSCTSLCTSB | |
| SCHEMBL9372986 | 0.84 | ATM (0.38) | ATMKLK5CTSSCTSLCTSB | |
| SCHEMBL9373933 | 0.84 | CTSK (0.39) | ATMKLK5CTSSCTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1450795-A1 | PEPTIDE ISOSTERES CONTAINING A HETEROCYCLE USEFUL IN THE TREATMENT OF ALZHEIMER'S DISEASE | Elan Pharmaceuticals, Inc. (US) | 2004-09-01 | — | — | EP | claimed |
| WO-2003047576-A1 | PEPTIDE ISOSTERES CONTAINING A HETEROCYCLE USEFUL IN THE TREATMENT OF ALZHEIMER'S DISEASE | ELAN PHARMACEUTICALS, INC. (US) | 2003-06-12 | — | — | WO | claimed |